{"id":"W1823881050","doi":"10.1016/j.dnarep.2015.08.004","title":"Constitutive stable DNA replication in Escherichia coli cells lacking type 1A topoisomerase activity","year":2015,"lang":"en","type":"article","venue":"DNA repair","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Topoisomerase; Escherichia coli; DNA replication; Replication (statistics); DNA; Genetics; Eukaryotic DNA replication; Cell biology; Molecular biology; Virology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004318362,0.0005195438,0.0003969739,0.0003479013,0.0002005461,0.0006857501,0.0005392002,0.0003498768,0.001056044],"category_scores_gemma":[0.000437206,0.0002522327,0.0002363122,0.0004401147,0.0003206658,0.0003207536,0.0002954029,0.0007632789,0.0005409128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007787792,"about_ca_system_score_gemma":0.0006291578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00198851,"about_ca_topic_score_gemma":0.002174195,"domain_scores_codex":[0.9995198,0.00008196036,0.00006511209,0.0000987387,0.0001505621,0.00008382146],"domain_scores_gemma":[0.9994599,0.0001043323,0.0001344355,0.0001463985,0.00008499754,0.00006999853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001293444,0.00003351969,0.0001416555,0.00002407621,0.000004139806,0.00001895926,0.00001102915,0.00004704547,0.9986312,0.000177523,0.00003190818,0.0007494906],"study_design_scores_gemma":[0.00001380612,0.0001366928,0.000781147,0.000004658907,0.000007456899,0.00006538031,0.00001367395,0.0005250804,0.9973998,0.00003718635,0.001010686,0.000004409652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857835,0.001242933,0.009314487,0.0001328238,0.0001033019,0.0001130111,0.001376641,0.0003585752,0.001574851],"genre_scores_gemma":[0.9868952,0.0004227956,0.006271414,0.00003135635,0.00001207447,0.00005661071,0.001399994,0.00006782979,0.004842667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00198851,"threshold_uncertainty_score":0.005650461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03132001682561627,"score_gpt":0.2841815403485462,"score_spread":0.25286152352293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}