{"id":"W1823881050","doi":"10.1016/j.dnarep.2015.08.004","title":"Constitutive stable DNA replication in Escherichia coli cells lacking type 1A topoisomerase activity","year":2015,"lang":"en","type":"article","venue":"DNA repair","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Topoisomerase; Escherichia coli; DNA replication; Replication (statistics); DNA; Genetics; Eukaryotic DNA replication; Cell biology; Molecular biology; Virology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002883164,0.0001109605,0.0001227233,0.00002867264,0.00003766208,0.00001597782,0.00008993812,0.0001116726,0.00001249029],"category_scores_gemma":[0.0000442195,0.0001158283,0.00004932133,0.0001357753,0.00004467012,0.000006721023,0.00006473128,0.00007939521,0.00001468008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007274264,"about_ca_system_score_gemma":0.0002372844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001799685,"about_ca_topic_score_gemma":0.0001859433,"domain_scores_codex":[0.9991776,0.00005121849,0.0001246492,0.0003605341,0.00009528528,0.0001907403],"domain_scores_gemma":[0.9992644,0.000006976589,0.000070396,0.000468678,0.0001027592,0.00008680825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002246761,0.00007838415,0.0002764316,0.000007283367,0.00002488316,0.000003973709,0.00009368541,0.00004631631,0.9965613,0.0004893808,0.001101342,0.00109233],"study_design_scores_gemma":[0.0004856744,0.0002088968,0.0002019435,0.000008261337,0.000009523408,0.000001827108,0.00009363074,0.0002689654,0.8384164,0.0001723056,0.1599939,0.0001387179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949721,0.0003055145,0.0005369828,0.000102187,0.0003126218,0.0002261974,0.00001500236,0.00003520962,0.003494169],"genre_scores_gemma":[0.9977598,0.0001024994,0.0005979222,0.0004289873,0.00009224815,0.00002447669,0.00003863571,0.00001510567,0.0009403429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1588925,"threshold_uncertainty_score":0.4723342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03132001682561627,"score_gpt":0.2841815403485462,"score_spread":0.25286152352293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}