{"id":"W1824591436","doi":"10.1186/ar1735","title":"Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes","year":2005,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Arthritis Network; Canadian Institutes of Health Research; Arthritis Society","keywords":"Proinflammatory cytokine; Matrix metalloproteinase; Matrix Metalloproteinase 3; Cell biology; Matrix (chemical analysis); Chemistry; Gene expression; Cytokine; Immunology; Gene; Medicine; Inflammation; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001169156,0.000366774,0.0006011963,0.0006168322,0.0002553698,0.0001081726,0.0002219387,0.0002427757,0.0007071923],"category_scores_gemma":[0.0001202152,0.0003114186,0.0002098863,0.000597459,0.0001499218,0.000460503,0.00009992596,0.0006339124,0.0004833481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002428455,"about_ca_system_score_gemma":0.0002113932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008289548,"about_ca_topic_score_gemma":0.0003503524,"domain_scores_codex":[0.9959962,0.0003966654,0.0005803359,0.000730508,0.001173041,0.001123266],"domain_scores_gemma":[0.9983422,0.0001082343,0.00007609247,0.0007764669,0.000268125,0.000428902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007630441,0.000552572,0.0008219202,0.00001910268,0.00003304885,0.0009413663,0.0004432723,0.000003542157,0.7837268,0.0001457676,0.0001286615,0.2124209],"study_design_scores_gemma":[0.0128914,0.002636591,0.002187863,0.0006297253,0.00000724513,0.0002489185,0.000231964,0.00005218231,0.968191,0.0005776889,0.01204863,0.0002967954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707318,0.02435799,0.00002056464,0.001354464,0.00006794678,0.002833264,0.000009910552,0.000163869,0.0004602],"genre_scores_gemma":[0.9815013,0.007348515,0.008354214,0.0001160263,0.0004081743,0.000907216,0.00005956871,0.00009004264,0.001214908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2121242,"threshold_uncertainty_score":0.9999338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03542281864318565,"score_gpt":0.3327966343347796,"score_spread":0.297373815691594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}