{"id":"W1825038471","doi":"10.1021/acs.analchem.5b00788","title":"Tandem Native Mass-Spectrometry on Antibody–Drug Conjugates and Submillion Da Antibody–Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector","year":2015,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thermo Fisher Scientific (Canada)","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Chemistry; Tandem mass spectrometry; Orbitrap; Mass spectrometry; Antibody-drug conjugate; Tandem mass tag; Conjugate; Antigen; Chromatography; Antibody; Monoclonal antibody; Quantitative proteomics; Biochemistry; Proteomics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000583599,0.0005911352,0.0009126131,0.0003115076,0.0002228777,0.0001910132,0.0002975283,0.0002892325,0.0003355746],"category_scores_gemma":[0.0003387695,0.0004231704,0.0001471225,0.001029505,0.0005845395,0.0001898124,0.00007094205,0.001084146,0.00006525015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001760601,"about_ca_system_score_gemma":0.0003574473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003160887,"about_ca_topic_score_gemma":0.00001354594,"domain_scores_codex":[0.9959447,0.0001300157,0.0004813258,0.0009900258,0.001515333,0.0009386263],"domain_scores_gemma":[0.9974812,0.0002715027,0.0001593511,0.0005138982,0.0004745846,0.001099476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003834493,0.0006091195,0.05234491,0.000431537,0.0005877887,0.0007544959,0.0001121818,0.00001322775,0.9378202,0.00211395,0.001317032,0.00006103465],"study_design_scores_gemma":[0.00471664,0.004338172,0.02116996,0.0009543583,0.0002524832,0.0001571369,0.0009075514,0.005380668,0.9564534,0.001827112,0.002668152,0.001174367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834882,0.0003148442,0.000204272,0.002905,0.00003217948,0.000504729,0.0001008537,0.0001279505,0.012322],"genre_scores_gemma":[0.9929892,0.0002334657,0.00113818,0.0003873821,0.000467633,0.00002295381,0.0005834016,0.00007676448,0.004100971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03117495,"threshold_uncertainty_score":0.999822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03177648424556092,"score_gpt":0.3391791794412682,"score_spread":0.3074026951957073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}