{"id":"W1825038471","doi":"10.1021/acs.analchem.5b00788","title":"Tandem Native Mass-Spectrometry on Antibody–Drug Conjugates and Submillion Da Antibody–Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector","year":2015,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thermo Fisher Scientific (Canada)","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Chemistry; Tandem mass spectrometry; Orbitrap; Mass spectrometry; Antibody-drug conjugate; Tandem mass tag; Conjugate; Antigen; Chromatography; Antibody; Monoclonal antibody; Quantitative proteomics; Biochemistry; Proteomics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005248096,0.0004647849,0.0003414234,0.0004342466,0.0002444798,0.0004107528,0.0004188947,0.0004494656,0.0009289427],"category_scores_gemma":[0.0004106178,0.0001658277,0.0001639439,0.0002709962,0.000298774,0.0005394259,0.0005285673,0.0005200836,0.000412532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003244718,"about_ca_system_score_gemma":0.0002563557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002712568,"about_ca_topic_score_gemma":0.000368216,"domain_scores_codex":[0.9996209,0.0000714927,0.00001893013,0.0000972244,0.0001562596,0.00003518414],"domain_scores_gemma":[0.9997928,0.00005971571,0.00005083909,0.00003143767,0.00004007541,0.0000251871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006568892,0.00001781101,0.0003041472,0.00004116212,0.00001820055,0.00009133766,0.00003230458,0.00009015687,0.9935492,0.0003261359,0.000137988,0.005325746],"study_design_scores_gemma":[0.00001490509,0.0001575392,0.003753351,0.000004942243,0.00001810539,0.0009460648,0.00003204851,0.006976553,0.9850789,0.0003017441,0.002705221,0.00001066004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8301106,0.003068913,0.1618948,0.0002291455,0.00006607106,0.00007458476,0.0004291817,0.001385959,0.002740661],"genre_scores_gemma":[0.8804061,0.001667682,0.1126172,0.0002543165,0.0000456712,0.0001269592,0.0006520596,0.00017385,0.004056158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009289427,"threshold_uncertainty_score":0.003107607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03177648424556092,"score_gpt":0.3391791794412682,"score_spread":0.3074026951957073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}