{"id":"W1825683130","doi":"10.1093/brain/awv199","title":"Alzheimer’s disease cerebrospinal fluid biomarker in cognitively normal subjects","year":2015,"lang":"en","type":"article","venue":"Brain","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; European Regional Development Fund; Avid Radiopharmaceuticals; University of California, San Diego; National Institutes of Health; Fondation pour la Recherche sur Alzheimer; Instituut Born-Bunge; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; Genentech; Vlaamse regering; Servier; Knut och Alice Wallenbergs Stiftelse; Vetenskapsrådet; Eisai; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; University of Southern California; AXA Research Fund; EU Joint Programme – Neurodegenerative Disease Research; Pfizer; Biogen; BioClinica; Australian Government; F. Hoffmann-La Roche; Agence Nationale de la Recherche; Synarc; European Federation of Pharmaceutical Industries and Associations; Medpace; Belgian Federal Science Policy Office; GlaxoSmithKline; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; Universiteit Antwerpen; Alzheimer's Association","keywords":"Cerebrospinal fluid; Neurodegeneration; Biomarker; Apolipoprotein E; Alzheimer's disease; Internal medicine; Amyloid (mycology); Medicine; Pathology; Pathological; Disease; Endocrinology; Psychology; Chemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006013825,0.0001514607,0.0001883403,0.0002314414,0.00003828404,0.00003251026,0.00008558665,0.00004969379,0.0004334503],"category_scores_gemma":[0.0005771848,0.0001358512,0.00007451283,0.0003540892,0.0001207491,0.0001512859,0.00008868687,0.0001513122,0.0004901036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000579263,"about_ca_system_score_gemma":0.000486984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007645923,"about_ca_topic_score_gemma":0.00002535784,"domain_scores_codex":[0.9983371,0.0001380321,0.0002052957,0.0002985398,0.0005489069,0.0004721387],"domain_scores_gemma":[0.9988577,0.00008967431,0.00003072619,0.0001580184,0.0002024103,0.0006614183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004560579,0.001021764,0.8977341,0.00006408358,0.0001429324,0.001782604,0.0002784584,3.692627e-7,0.004417658,0.0001835371,0.03866817,0.05114573],"study_design_scores_gemma":[0.005555912,0.0004983924,0.9808643,0.0001073971,0.00008023003,0.0000338229,0.0002789051,0.0002471263,0.001469874,0.0001745342,0.01052719,0.0001623063],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9529723,0.0006725873,0.0001062294,0.005467468,0.00009446694,0.0006996364,0.0000224552,0.00005266339,0.03991218],"genre_scores_gemma":[0.9954315,0.000009149192,0.00009497053,0.001974715,0.0001013871,0.00007377144,0.00009938458,0.00002211913,0.002192971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0831302,"threshold_uncertainty_score":0.6299454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0686518149714463,"score_gpt":0.3507942277712879,"score_spread":0.2821424127998416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}