{"id":"W1825683130","doi":"10.1093/brain/awv199","title":"Alzheimer’s disease cerebrospinal fluid biomarker in cognitively normal subjects","year":2015,"lang":"en","type":"article","venue":"Brain","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; European Regional Development Fund; Avid Radiopharmaceuticals; University of California, San Diego; National Institutes of Health; Fondation pour la Recherche sur Alzheimer; Instituut Born-Bunge; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; Genentech; Vlaamse regering; Servier; Knut och Alice Wallenbergs Stiftelse; Vetenskapsrådet; Eisai; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; University of Southern California; AXA Research Fund; EU Joint Programme – Neurodegenerative Disease Research; Pfizer; Biogen; BioClinica; Australian Government; F. Hoffmann-La Roche; Agence Nationale de la Recherche; Synarc; European Federation of Pharmaceutical Industries and Associations; Medpace; Belgian Federal Science Policy Office; GlaxoSmithKline; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; Universiteit Antwerpen; Alzheimer's Association","keywords":"Cerebrospinal fluid; Neurodegeneration; Biomarker; Apolipoprotein E; Alzheimer's disease; Internal medicine; Amyloid (mycology); Medicine; Pathology; Pathological; Disease; Endocrinology; Psychology; Chemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008080893,0.0005840164,0.0007295419,0.001443455,0.0006713665,0.0009347404,0.000378137,0.0005760344,0.0006016578],"category_scores_gemma":[0.002760062,0.0003338757,0.0003176956,0.001152948,0.0004612926,0.0004202654,0.0005296236,0.000334473,0.0002734259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004251887,"about_ca_system_score_gemma":0.0002967409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006219553,"about_ca_topic_score_gemma":0.004258478,"domain_scores_codex":[0.9993781,0.0001225943,0.00005658501,0.0002213249,0.0001375651,0.00008371819],"domain_scores_gemma":[0.9991334,0.0001275057,0.0002552491,0.0001108243,0.0001893779,0.0001836729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001243053,0.0001553858,0.9904091,0.00003142661,0.0001200471,0.0005932069,0.000612711,0.0000537512,0.002992378,0.00002391043,0.0001612169,0.003603782],"study_design_scores_gemma":[0.00002634852,0.0002683444,0.9986588,0.000003571967,0.00002752229,0.0005091067,0.00009925874,0.00006485207,0.0001672135,0.00002525325,0.0001448385,0.000004833461],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996284,0.0001263843,0.00003779196,0.00000585103,0.000002863096,0.000006196054,0.00009792761,0.000002184915,0.00009230161],"genre_scores_gemma":[0.9993458,0.00006582244,0.00007638361,0.00002276125,0.000009389447,0.0000119883,0.0003221438,0.000002377314,0.0001432821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006219553,"threshold_uncertainty_score":0.01236671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0686518149714463,"score_gpt":0.3507942277712879,"score_spread":0.2821424127998416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}