{"id":"W1825815388","doi":"10.4049/jimmunol.172.1.318","title":"Dexamethasone Inhibits IL-12p40 Production in Lipopolysaccharide-Stimulated Human Monocytic Cells by Down-Regulating the Activity of c-Jun N-Terminal Kinase, the Activation Protein-1, and NF-κB Transcription Factors","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; University of Ottawa; Children's Hospital of Eastern Ontario","funders":"","keywords":"Kinase; MAPK/ERK pathway; Biology; CD14; Transcription factor; Molecular biology; Protein kinase A; Cell biology; Transcription (linguistics); c-jun; p38 mitogen-activated protein kinases; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001572737,0.0002128421,0.0003619114,0.0002107617,0.0004288465,0.00001754037,0.0003039225,0.0002530641,0.00002024665],"category_scores_gemma":[0.0002090497,0.0001141938,0.00009261334,0.0002361005,0.0005669301,0.0004082655,0.00005290963,0.0008798947,0.00000364243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001442001,"about_ca_system_score_gemma":0.00009603088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008587613,"about_ca_topic_score_gemma":0.0000554018,"domain_scores_codex":[0.9975667,0.001211943,0.0007066883,0.0001487037,0.00008908198,0.0002768794],"domain_scores_gemma":[0.9982413,0.0002947912,0.0009965134,0.000294629,0.0001628902,0.000009858065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001547108,0.0001293604,0.00005259231,0.00001750737,0.0001693017,6.679126e-7,0.004538664,0.0007284468,0.9868729,0.00007018127,0.00001337833,0.005859905],"study_design_scores_gemma":[0.00164808,0.0006427406,0.006401956,0.0001921187,0.00008915191,0.0001652002,0.001278231,0.00001503235,0.9889563,0.0004293896,0.00006880709,0.0001129863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955806,0.001197547,0.0002961549,0.002031629,0.000261823,0.0006104336,0.000003281148,0.00001238726,0.000006148217],"genre_scores_gemma":[0.9996153,0.0001882991,0.00001572794,0.00001651532,0.00003057055,0.000008968007,0.000007352758,0.00001521215,0.0001020855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006349363,"threshold_uncertainty_score":0.4656689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01515701505024228,"score_gpt":0.2373090727278808,"score_spread":0.2221520576776385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}