{"id":"W1825815388","doi":"10.4049/jimmunol.172.1.318","title":"Dexamethasone Inhibits IL-12p40 Production in Lipopolysaccharide-Stimulated Human Monocytic Cells by Down-Regulating the Activity of c-Jun N-Terminal Kinase, the Activation Protein-1, and NF-κB Transcription Factors","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; University of Ottawa; Children's Hospital of Eastern Ontario","funders":"","keywords":"Kinase; MAPK/ERK pathway; Biology; CD14; Transcription factor; Molecular biology; Protein kinase A; Cell biology; Transcription (linguistics); c-jun; p38 mitogen-activated protein kinases; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001499566,0.0004847553,0.0002795154,0.000184609,0.0001411343,0.0001852482,0.0001363999,0.0001764954,0.0009909421],"category_scores_gemma":[0.0001112476,0.0001352051,0.000262515,0.0001428002,0.000203242,0.00009901346,0.0001332921,0.0005940886,0.0002885267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000160783,"about_ca_system_score_gemma":0.0003723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005300478,"about_ca_topic_score_gemma":0.001187077,"domain_scores_codex":[0.999851,0.00002959496,0.00002200356,0.00001665519,0.00004321758,0.00003744048],"domain_scores_gemma":[0.9999336,0.00001477174,0.00001441074,0.00000955471,0.000008382862,0.00001926956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000288695,0.00008036281,0.0001026594,0.00006745571,0.000004219425,0.00004774876,0.00001643997,0.00003374818,0.9976709,0.00004013187,0.00002871659,0.001619],"study_design_scores_gemma":[0.0001105988,0.001201525,0.003801307,0.00001064805,0.00001751589,0.0001775751,0.0000331504,0.000403263,0.990849,0.00004334138,0.003347406,0.000004748578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828178,0.01105008,0.003283392,0.0002485313,0.0001544406,0.00007938805,0.000517018,0.00009841063,0.001751116],"genre_scores_gemma":[0.9870188,0.006390001,0.003203118,0.00009660209,0.0000433766,0.0001098615,0.0006492281,0.00001127838,0.002477559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009909421,"threshold_uncertainty_score":0.003315091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01515701505024228,"score_gpt":0.2373090727278808,"score_spread":0.2221520576776385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}