{"id":"W1826152418","doi":"10.1002/jgm.2836","title":"Potent immunotherapy against well‐established thymoma using adoptively transferred transgene <i>IL‐6</i>‐engineered dendritic cell‐stimulated CD8<sup>+</sup> T‐cells with prolonged survival and enhanced cytotoxicity","year":2015,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"Cytotoxic T cell; Interleukin 21; Perforin; CD8; Biology; Molecular biology; Population; T cell; Antigen-presenting cell; Antigen; Immunology; Cancer research; Immune system; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002206748,0.0005349694,0.00110837,0.0003129267,0.0003042296,0.00002627773,0.000555393,0.0002893247,0.00008043843],"category_scores_gemma":[0.00007087313,0.0003158553,0.000151234,0.0004391201,0.0007609624,0.0002470283,0.00002255745,0.0008756522,0.000009790529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001202784,"about_ca_system_score_gemma":0.0003710911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008427282,"about_ca_topic_score_gemma":0.000006037534,"domain_scores_codex":[0.996447,0.001306352,0.001050102,0.0002747345,0.0002870954,0.000634731],"domain_scores_gemma":[0.9980515,0.0004460202,0.0004246848,0.0004238491,0.000533313,0.0001206051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0203675,0.0002545507,0.00002939684,0.00003099072,0.0008521463,0.00005045196,0.008721763,0.01030395,0.9581029,0.000001975277,0.0001087999,0.001175571],"study_design_scores_gemma":[0.02245016,0.005151475,0.0007311251,0.000339611,0.0004727429,0.00111395,0.004815159,0.0005354168,0.9632568,0.00001263082,0.000707701,0.0004132382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9498296,0.03159815,0.01661957,0.0006040302,0.0005291554,0.0006393203,0.00002171336,0.00004189747,0.0001166076],"genre_scores_gemma":[0.9950068,0.003627734,0.0004948086,0.0003067656,0.0001309019,0.000005568074,0.00002388383,0.00008003844,0.0003235068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04517724,"threshold_uncertainty_score":0.9999294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01964269388852232,"score_gpt":0.2331861572773492,"score_spread":0.2135434633888268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}