{"id":"W1826152418","doi":"10.1002/jgm.2836","title":"Potent immunotherapy against well‐established thymoma using adoptively transferred transgene <i>IL‐6</i>‐engineered dendritic cell‐stimulated CD8<sup>+</sup> T‐cells with prolonged survival and enhanced cytotoxicity","year":2015,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"Cytotoxic T cell; Interleukin 21; Perforin; CD8; Biology; Molecular biology; Population; T cell; Antigen-presenting cell; Antigen; Immunology; Cancer research; Immune system; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001167909,0.0005698886,0.0003202036,0.0001279594,0.00007628747,0.0002643326,0.0001702426,0.0002996615,0.0006244495],"category_scores_gemma":[0.00006932469,0.00008681093,0.0002217908,0.00009426672,0.0001362799,0.0001646106,0.0001503731,0.0007596297,0.0003086551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001099756,"about_ca_system_score_gemma":0.0001403208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009249167,"about_ca_topic_score_gemma":0.0001537318,"domain_scores_codex":[0.9999067,0.0000108182,0.00001099637,0.0000196318,0.00001835681,0.00003360747],"domain_scores_gemma":[0.9999193,0.00001529313,0.00002456401,0.00001109021,0.000009069481,0.00002071486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001103949,0.00009787815,0.0001224453,0.00004214214,0.000004881378,0.00004631168,0.000009145857,0.00008107569,0.9980056,0.00002974691,0.00004151617,0.001408952],"study_design_scores_gemma":[0.00008244707,0.001628869,0.001574193,0.000008589494,0.00004065626,0.0006647859,0.00001312243,0.0008938828,0.993225,0.00002934917,0.001835737,0.000003277847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930986,0.00138184,0.003956867,0.00005108484,0.0000495426,0.00006171288,0.0001996399,0.0001258047,0.001074936],"genre_scores_gemma":[0.9949145,0.0008255684,0.002185829,0.00004079461,0.00003093332,0.00005646018,0.0003594337,0.00001792077,0.001568519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006244495,"threshold_uncertainty_score":0.002088964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01964269388852232,"score_gpt":0.2331861572773492,"score_spread":0.2135434633888268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}