{"id":"W1826532164","doi":"10.1111/j.1750-3639.2010.00372.x","title":"Telomerase Inhibition as a Novel Therapy for Pediatric Ependymoma","year":2010,"lang":"en","type":"article","venue":"Brain Pathology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Telomerase; Telomerase reverse transcriptase; Telomere; Ependymoma; Biology; Cancer research; Apoptosis; Glial fibrillary acidic protein; Molecular biology; Immunology; Pathology; Medicine; DNA; Immunohistochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004337846,0.0002383464,0.0003822847,0.0002999618,0.0001406447,0.00001793516,0.0001096065,0.0003305505,0.0003274898],"category_scores_gemma":[0.0008819858,0.0002094232,0.000161007,0.000294528,0.0001423256,0.0000890318,0.00003275204,0.0004021972,0.0001603872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001925764,"about_ca_system_score_gemma":0.0002053348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002182202,"about_ca_topic_score_gemma":0.00003318044,"domain_scores_codex":[0.9984206,0.00004126816,0.0003473646,0.0005198125,0.0001918099,0.0004791191],"domain_scores_gemma":[0.9986944,0.0003549164,0.0001266993,0.0004466466,0.0001622678,0.0002150788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007692171,0.0008031575,0.01044004,0.00009593585,0.0000226569,0.0008825692,0.0006981714,3.665166e-7,0.9381217,0.004034383,0.007967434,0.03616435],"study_design_scores_gemma":[0.03837821,0.006671036,0.5043569,0.00006763548,0.0002701286,0.02819081,0.000544735,0.0002141837,0.2156807,0.008051245,0.1957052,0.00186926],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898829,0.0002332598,0.00127715,0.005706472,0.000771297,0.0009217621,0.00005343874,0.0001659079,0.0009878299],"genre_scores_gemma":[0.9820319,0.000101207,0.005985362,0.008755372,0.001328676,0.0001934056,0.0001362726,0.00005676454,0.001411017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.722441,"threshold_uncertainty_score":0.8540031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01933005242839701,"score_gpt":0.2978154627520141,"score_spread":0.2784854103236171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}