{"id":"W1827149984","doi":"10.1074/jbc.m115.648204","title":"Pore-forming Activity of the Escherichia coli Type III Secretion System Protein EspD","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies; Canada Foundation for Innovation","keywords":"Secretion; Vesicle; Escherichia coli; Bacterial outer membrane; Biology; Type three secretion system; Cytosol; Lipid bilayer; Cell biology; Chemistry; Microbiology; Biophysics; Biochemistry; Virulence; Membrane; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001498951,0.0001618631,0.0001142662,0.0001377163,0.00009221786,0.0002750857,0.00008793219,0.0002088578,0.0004989573],"category_scores_gemma":[0.0002713072,0.00007234163,0.0002206587,0.00009915131,0.0001720762,0.0001555679,0.0002045432,0.0002665856,0.0002049475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000303217,"about_ca_system_score_gemma":0.0001261934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000327717,"about_ca_topic_score_gemma":0.0001690509,"domain_scores_codex":[0.9999195,0.00001779372,0.0000078896,0.00001823922,0.00002254536,0.0000140338],"domain_scores_gemma":[0.999898,0.00003225843,0.00001438537,0.000013056,0.0000209368,0.00002132998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004246973,0.00001369175,0.0004019351,0.00002254688,0.000003550694,0.00003590427,0.00001112288,0.00003423207,0.9987355,0.00009213197,0.00001940044,0.0005875707],"study_design_scores_gemma":[0.000008779912,0.0001125327,0.005112072,0.000005610923,0.00000676124,0.0002798681,0.00002559186,0.001091813,0.9921634,0.0000625771,0.001127425,0.0000035997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958633,0.0007581646,0.002421318,0.00006676459,0.0000143136,0.000008395238,0.0001994829,0.00002230589,0.0006459889],"genre_scores_gemma":[0.997319,0.0002044577,0.001279415,0.00003697601,0.000002770039,0.000005414704,0.0005208502,0.000006413394,0.0006247503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004989573,"threshold_uncertainty_score":0.002200067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03487215495337807,"score_gpt":0.2816813759007641,"score_spread":0.246809220947386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}