{"id":"W1827491256","doi":"","title":"Integrated analysis of epigenomic and genomic changes by DNA methylation dependent mechanisms provides potential novel biomarkers for prostate cancer","year":2014,"lang":"en","type":"article","venue":"PubMed Central","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"","keywords":"Epigenomics; DNA methylation; Prostate cancer; Cancer; Medicine; Epigenetics; Cancer research; Methylation; Computational biology; DNA; Bioinformatics; Biology; Genetics; Internal medicine; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000486938,0.0001459583,0.0002091965,0.0001160903,0.00005619169,0.00002840738,0.00008867819,0.0001154548,0.000004595358],"category_scores_gemma":[0.00006842097,0.0001368182,0.00008977578,0.0001271851,0.00004249434,0.000004642376,0.00003846121,0.00003245892,7.894839e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005176067,"about_ca_system_score_gemma":0.00005096201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001926927,"about_ca_topic_score_gemma":0.0008705413,"domain_scores_codex":[0.9988189,0.00005192606,0.0002259395,0.0003448282,0.00009808159,0.0004603429],"domain_scores_gemma":[0.9994404,0.00001496051,0.0001869241,0.000146029,0.00007671448,0.0001349783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001464435,0.00003540375,0.003549702,0.00002395661,0.0006637109,4.077814e-8,0.00006886013,0.0009185482,0.9540433,0.00003992168,0.00001432479,0.04049578],"study_design_scores_gemma":[0.0007485403,0.0001359172,0.0638081,0.000003241381,0.0006037153,1.987267e-7,0.00005111183,0.009459267,0.9233896,0.0001605824,0.001456158,0.000183575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.850703,0.0014159,0.1466075,0.0001134097,0.0001667059,0.0005708243,0.0004086456,0.000006191483,0.000007841989],"genre_scores_gemma":[0.9960608,0.0006474161,0.001965826,0.00003372872,0.00008071902,0.0002170247,0.0008891037,0.00002058164,0.00008474743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1453578,"threshold_uncertainty_score":0.5579284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009072227242593756,"score_gpt":0.2249381873463437,"score_spread":0.2158659601037499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}