{"id":"W1827943802","doi":"10.1111/bph.12134","title":"Pharmacology of <scp>AMG</scp> 181, a human anti‐α<sub>4</sub>β<sub>7</sub> antibody that specifically alters trafficking of gut‐homing <scp>T</scp> cells","year":2013,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada)","funders":"Amgen","keywords":"Addressin; Pharmacology; Pharmacokinetics; Chemistry; Immunogenicity; Bioavailability; Pharmacodynamics; Cell adhesion molecule; Homing (biology); Antibody; Receptor; Integrin; Medicine; Immunology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001127712,0.0003861455,0.0002716185,0.0002664133,0.0001550597,0.0002895297,0.000221742,0.0003456491,0.001452726],"category_scores_gemma":[0.0001528065,0.0001731197,0.0002592966,0.0001419641,0.0003346233,0.0002628937,0.00007328517,0.0009954026,0.0005928772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005024828,"about_ca_system_score_gemma":0.0004612608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009965659,"about_ca_topic_score_gemma":0.001378084,"domain_scores_codex":[0.9999161,0.00002201481,0.000003211384,0.00001617915,0.0000149311,0.00002762667],"domain_scores_gemma":[0.9998945,0.00002015408,0.00003160314,0.00001358198,0.00001147289,0.00002868441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003855467,0.001217251,0.0006867996,0.0001089261,0.00003748809,0.0001024671,0.00003780201,0.0006413069,0.9763054,0.0001444496,0.0007450299,0.01611773],"study_design_scores_gemma":[0.001064261,0.07184856,0.02124185,0.00002713632,0.0001541794,0.001280747,0.0000609973,0.002518513,0.8927782,0.0001789377,0.008820369,0.00002626037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99403,0.001237054,0.001210823,0.0001564073,0.00004495385,0.0001392923,0.0004371796,0.0001339191,0.002610513],"genre_scores_gemma":[0.9948704,0.0009321636,0.001324421,0.0001397468,0.00004034494,0.0001279743,0.0005268864,0.00002690217,0.002011145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001452726,"threshold_uncertainty_score":0.004859805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02664284297848672,"score_gpt":0.3183329319364558,"score_spread":0.2916900889579691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}