{"id":"W1828494712","doi":"10.1200/jco.2000.18.19.3360","title":"Effect of Radiotherapy After Breast-Conserving Treatment in Women With Breast Cancer and Germline BRCA1/2 Mutations","year":2000,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":268,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Breast cancer; Oncology; Radiation therapy; Internal medicine; Cohort; Estrogen receptor; Germline mutation; Cancer; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"design_other","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"medium","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008859539,0.0001231075,0.0005949794,0.00006265524,0.00001759355,0.000005837692,0.00009309789,0.0001942782,0.0003089882],"category_scores_gemma":[0.00004987776,0.00008195345,0.00009642676,0.0000936399,0.0002114418,0.000008714397,0.00001251931,0.0001577074,6.645853e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002051621,"about_ca_system_score_gemma":0.0009385261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007373178,"about_ca_topic_score_gemma":0.0002794558,"domain_scores_codex":[0.9984075,0.0003400357,0.0008184255,0.0001736923,0.00009835053,0.0001619766],"domain_scores_gemma":[0.998884,0.0003108633,0.0004256375,0.0001393014,0.000121249,0.0001189927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01766491,0.0004111085,0.1180759,0.00001987382,0.0004347753,0.00005834266,0.0002403354,0.0009255775,0.002937051,6.111649e-7,0.0001017269,0.8591298],"study_design_scores_gemma":[0.01287542,0.01810217,0.9511581,0.00008308561,0.0001436715,0.00124859,0.00006009005,0.0001005786,0.001650103,0.0000227657,0.01440001,0.0001554244],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995871,0.001711612,0.00002936835,0.001992625,0.0001193765,0.0001412056,0.00003599366,0.000001436876,0.00009736134],"genre_scores_gemma":[0.9949863,0.002940058,0.0009594606,0.0004845512,0.0004155358,0.00004899933,0.0000021209,0.00001544968,0.0001475294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8589743,"threshold_uncertainty_score":0.3383204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01434391743818245,"score_gpt":0.3846752919627554,"score_spread":0.3703313745245729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}