{"id":"W182876071","doi":"10.4049/jimmunol.182.supp.49.21","title":"A B cell intrinsic defect initiates autoimmunity in New Zealand Black chromosome 13 congenic mice (49.21)","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arthritis Research Centre of Canada; University of Toronto","funders":"","keywords":"Congenic; Biology; Transgene; Autoimmunity; Genetically modified mouse; Phenotype; breakpoint cluster region; B cell; Chimera (genetics); Adoptive cell transfer; Cell biology; Immune system; Systemic lupus erythematosus; Bone marrow; Molecular biology; T cell; Immunology; Genetics; Antibody; Receptor; Gene; Disease; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004055744,0.001021599,0.0004191248,0.001052839,0.0003604888,0.0005127955,0.0004138549,0.0008210118,0.003790363],"category_scores_gemma":[0.0003181081,0.0004175203,0.0004447826,0.0003292123,0.0006127762,0.0002675259,0.0005226407,0.001365995,0.001240118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004427078,"about_ca_system_score_gemma":0.0002396489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001084508,"about_ca_topic_score_gemma":0.001473034,"domain_scores_codex":[0.9994121,0.0001084562,0.00006560882,0.0001287007,0.0001781617,0.0001070052],"domain_scores_gemma":[0.9990364,0.0001135625,0.0004231311,0.00006920372,0.00004558853,0.0003121174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001109932,0.00004618547,0.0002745819,0.00001711172,0.000006031709,0.0001695657,0.00001616862,0.00002792419,0.9987974,0.0001416669,0.00002322987,0.0003691429],"study_design_scores_gemma":[0.000145133,0.001085611,0.0268924,0.00004641151,0.00006035684,0.003621288,0.00005645235,0.001268469,0.9627124,0.0001420577,0.003947882,0.00002145859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993398,0.0003913766,0.002778026,0.00008066367,0.00002654441,0.000049894,0.0005474179,0.0001396998,0.002588491],"genre_scores_gemma":[0.9832877,0.0007172259,0.005814712,0.00008788356,0.00002836709,0.00008455395,0.001405729,0.0001877118,0.008386171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003790363,"threshold_uncertainty_score":0.01267999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01144949302668295,"score_gpt":0.2221625964656658,"score_spread":0.2107131034389829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}