{"id":"W1829579785","doi":"10.1111/1751-7915.12315","title":"Experimental validation of <i>in silico</i> model‐predicted isocitrate dehydrogenase and phosphomannose isomerase from <scp> <i>D</i> </scp> <i>ehalococcoides mccartyi</i>","year":2015,"lang":"en","type":"article","venue":"Microbial Biotechnology","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto; Ontario Genomics Institute; Genome Canada","keywords":"In silico; Isomerase; Isocitrate dehydrogenase; Computational biology; Glucose-6-phosphate isomerase; Genome; Gene; Biochemistry; Biology; Genome project; Protein superfamily; Dehydrogenase; Chemistry; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008682602,0.0009535717,0.0007572525,0.000384997,0.0006031121,0.0008819381,0.000811224,0.0009073422,0.001441095],"category_scores_gemma":[0.001569183,0.0003671565,0.0009006213,0.0007639512,0.0005040738,0.0004503059,0.0006978342,0.0008416304,0.001176472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009738642,"about_ca_system_score_gemma":0.0009794259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009200471,"about_ca_topic_score_gemma":0.006204849,"domain_scores_codex":[0.9990014,0.0001231613,0.00007076916,0.0003700271,0.0003222565,0.0001123384],"domain_scores_gemma":[0.9989988,0.0003198814,0.0001292201,0.0001638133,0.0002898756,0.00009842377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004008012,0.0001774324,0.003589336,0.0002585677,0.00003537922,0.0001650848,0.00008992452,0.006027364,0.9858155,0.0001539492,0.0002872019,0.002999347],"study_design_scores_gemma":[0.00004744012,0.0004760943,0.01093057,0.00002474067,0.00008271117,0.0001978135,0.0001686035,0.048146,0.9356678,0.0001446188,0.004068095,0.00004549854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777075,0.0003319619,0.0142326,0.0001560811,0.0000829638,0.00006629026,0.00540373,0.0006081713,0.001410771],"genre_scores_gemma":[0.9398516,0.0004981969,0.03362291,0.0001348081,0.00001737662,0.0001414392,0.02394627,0.0003747471,0.001412733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009200471,"threshold_uncertainty_score":0.01829386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01138077646906156,"score_gpt":0.2171735948975687,"score_spread":0.2057928184285072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}