{"id":"W1829579785","doi":"10.1111/1751-7915.12315","title":"Experimental validation of <i>in silico</i> model‐predicted isocitrate dehydrogenase and phosphomannose isomerase from <scp> <i>D</i> </scp> <i>ehalococcoides mccartyi</i>","year":2015,"lang":"en","type":"article","venue":"Microbial Biotechnology","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto; Ontario Genomics Institute; Genome Canada","keywords":"In silico; Isomerase; Isocitrate dehydrogenase; Computational biology; Glucose-6-phosphate isomerase; Genome; Gene; Biochemistry; Biology; Genome project; Protein superfamily; Dehydrogenase; Chemistry; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002228401,0.0002642061,0.0003962643,0.000188173,0.00007073148,0.000037915,0.0002534436,0.0005326808,0.0000219207],"category_scores_gemma":[0.0001059488,0.0002619007,0.00005693781,0.000337171,0.0004212319,0.0002540814,0.000177498,0.0002268266,0.0000275664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007965459,"about_ca_system_score_gemma":0.00008391224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007047502,"about_ca_topic_score_gemma":0.00007687429,"domain_scores_codex":[0.9983484,0.00007997257,0.0004737773,0.000558677,0.0001567837,0.0003823851],"domain_scores_gemma":[0.999188,0.00006463053,0.0002081942,0.0003597522,0.00007069002,0.0001087489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005845714,0.0001136093,0.0002142026,0.000009420503,0.00001019805,0.00001127576,0.0006601518,0.0005310414,0.9951545,0.0001497155,0.002967642,0.0001197707],"study_design_scores_gemma":[0.00163924,0.0001973993,0.00002187268,0.0000237494,0.00002572139,0.00002128551,0.0005517153,0.0007141149,0.9946747,0.001026526,0.000989682,0.000113944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965752,0.001326149,0.0005338747,0.0001553584,0.0003518297,0.0002898856,0.0003994034,0.0002108617,0.0001574409],"genre_scores_gemma":[0.9969723,0.00005286165,0.002363874,0.00034061,0.00005895478,0.00002179034,0.0001152855,0.00002707602,0.00004724681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00197796,"threshold_uncertainty_score":0.9999833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01138077646906156,"score_gpt":0.2171735948975687,"score_spread":0.2057928184285072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}