{"id":"W1830119115","doi":"10.1002/mbo3.286","title":"Loss of membrane‐bound lytic transglycosylases increases outer membrane permeability and <i>β</i>‐lactam sensitivity in <i>Pseudomonas aeruginosa</i>","year":2015,"lang":"en","type":"article","venue":"MicrobiologyOpen","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cystic Fibrosis Canada; McMaster University","keywords":"Pseudomonas aeruginosa; Mutant; Peptidoglycan; Cell envelope; Bacterial outer membrane; Microbiology; Biology; Complementation; Lytic cycle; Cefotaxime; Bacterial cell structure; Multidrug tolerance; Lipid II; Biochemistry; Chemistry; Cell wall; Bacteria; Antibiotics; Biofilm; Genetics; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008193159,0.0002988093,0.000545588,0.00006409081,0.00004287257,0.00002634729,0.0002306279,0.0003063142,0.00002312727],"category_scores_gemma":[0.0002125684,0.0002727058,0.00009754558,0.0001105046,0.0007877396,0.00001770498,0.0002083554,0.0001406448,0.000009429403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003610196,"about_ca_system_score_gemma":0.0001881796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000617463,"about_ca_topic_score_gemma":0.001943061,"domain_scores_codex":[0.9980488,0.0003736551,0.0004627672,0.0006443422,0.00007917194,0.0003913072],"domain_scores_gemma":[0.9989888,0.00009103079,0.0001446079,0.0005114967,0.0001267697,0.0001372878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006735773,0.0001736912,0.2185843,0.00008397197,0.00004233568,0.00003413284,0.00009664199,0.00001185111,0.7799199,0.00001204286,0.0003057306,0.00006187567],"study_design_scores_gemma":[0.002638882,0.0003509219,0.07808667,0.00007936681,0.00005205897,0.0006077252,0.0002166106,0.00001151126,0.9141171,0.00004274234,0.003322705,0.0004737288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981584,0.0004334219,0.00004945161,0.0001470867,0.0001069997,0.0004359063,0.0002032654,0.00001308402,0.0004523965],"genre_scores_gemma":[0.9985792,0.0001435385,0.0004931296,0.0002917514,0.00006927484,0.000007044247,0.0002120261,0.00002602581,0.0001780144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1404976,"threshold_uncertainty_score":0.9999725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01307222013495229,"score_gpt":0.241612876006161,"score_spread":0.2285406558712087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}