{"id":"W1830119115","doi":"10.1002/mbo3.286","title":"Loss of membrane‐bound lytic transglycosylases increases outer membrane permeability and <i>β</i>‐lactam sensitivity in <i>Pseudomonas aeruginosa</i>","year":2015,"lang":"en","type":"article","venue":"MicrobiologyOpen","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cystic Fibrosis Canada; McMaster University","keywords":"Pseudomonas aeruginosa; Mutant; Peptidoglycan; Cell envelope; Bacterial outer membrane; Microbiology; Biology; Complementation; Lytic cycle; Cefotaxime; Bacterial cell structure; Multidrug tolerance; Lipid II; Biochemistry; Chemistry; Cell wall; Bacteria; Antibiotics; Biofilm; Genetics; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001032449,0.0004880113,0.0003711244,0.0001890498,0.000111494,0.0003942433,0.0002929011,0.0003052433,0.0009030277],"category_scores_gemma":[0.000236501,0.0002237395,0.0003747035,0.000187792,0.0002128985,0.0002310652,0.0003025168,0.0006507942,0.0002886703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002950854,"about_ca_system_score_gemma":0.0001555653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001462618,"about_ca_topic_score_gemma":0.001118472,"domain_scores_codex":[0.9996669,0.00004227494,0.00004240342,0.00006108142,0.0001157788,0.00007150608],"domain_scores_gemma":[0.9997749,0.00003202482,0.00009497007,0.00002466563,0.00002231037,0.00005111967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002864106,0.00002083232,0.0001709363,0.000009633517,0.000002567151,0.00003300633,0.000005792899,0.00001727538,0.9993654,0.000007754277,0.00001254489,0.0003255866],"study_design_scores_gemma":[0.000005989851,0.0003556503,0.01109359,0.000006361429,0.00001528514,0.0004404488,0.00004633247,0.0005455867,0.9866998,0.00001393877,0.000769358,0.000007590006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978495,0.00038418,0.0008719596,0.00008531151,0.00001449786,0.0000171994,0.0002346162,0.00006067571,0.0004819549],"genre_scores_gemma":[0.9967811,0.0003092556,0.001139676,0.00005540625,0.000008479225,0.00002595677,0.0004114618,0.00003579139,0.00123283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001462618,"threshold_uncertainty_score":0.003020942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01307222013495229,"score_gpt":0.241612876006161,"score_spread":0.2285406558712087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}