{"id":"W1830479467","doi":"10.1111/j.1365-4632.2010.04512.x","title":"Safety profile of intravenous and subcutaneous siplizumab, an anti‐CD2 monoclonal antibody, for the treatment of plaque psoriasis: results of two randomized, double‐blind, placebo‐controlled studies","year":2010,"lang":"en","type":"article","venue":"International Journal of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada); Probity Medical Research; Dalhousie University","funders":"","keywords":"Medicine; Double blind; Placebo; Plaque psoriasis; Randomized controlled trial; Monoclonal antibody; Psoriasis; Dermatology; Monoclonal; Antibody; Internal medicine; Pathology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004155264,0.0002392409,0.001581661,0.0002800321,0.00008683761,0.000008020713,0.0003607494,0.0002038517,0.0000350135],"category_scores_gemma":[0.0002838452,0.000140328,0.0004245904,0.00005623681,0.0006489141,0.00009428294,0.00003813173,0.0001481382,0.000001534682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003036765,"about_ca_system_score_gemma":0.0002102323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008242318,"about_ca_topic_score_gemma":0.0001595897,"domain_scores_codex":[0.997639,0.0003350377,0.001522368,0.0001910554,0.000112365,0.0002001878],"domain_scores_gemma":[0.9939139,0.003227745,0.001724147,0.0001941116,0.0009057056,0.00003434144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8943147,0.001178034,0.0008283694,0.00003130315,0.01330684,0.0001640177,0.00294852,0.00006075233,0.07350162,0.003879879,0.00005784487,0.009728134],"study_design_scores_gemma":[0.7981879,0.001710738,0.0002885874,0.00006909751,0.001852689,0.01378652,0.0007306163,0.0001132142,0.1814429,0.0008417544,0.0008167738,0.0001592613],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881949,0.006674694,0.0002092122,0.00117409,0.00232108,0.001031481,0.0002908022,0.000006497015,0.00009728895],"genre_scores_gemma":[0.9939408,0.004969279,0.0006977775,0.00001065268,0.0001316392,0.00005565862,0.00008760897,0.00001338415,0.00009324527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1079413,"threshold_uncertainty_score":0.5722411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02345223868321901,"score_gpt":0.3236762313714055,"score_spread":0.3002239926881865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}