{"id":"W1830479467","doi":"10.1111/j.1365-4632.2010.04512.x","title":"Safety profile of intravenous and subcutaneous siplizumab, an anti‐CD2 monoclonal antibody, for the treatment of plaque psoriasis: results of two randomized, double‐blind, placebo‐controlled studies","year":2010,"lang":"en","type":"article","venue":"International Journal of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada); Probity Medical Research; Dalhousie University","funders":"","keywords":"Medicine; Double blind; Placebo; Plaque psoriasis; Randomized controlled trial; Monoclonal antibody; Psoriasis; Dermatology; Monoclonal; Antibody; Internal medicine; Pathology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006634142,0.001233166,0.003021383,0.0005708644,0.000349566,0.0008124762,0.0008262864,0.002063969,0.002621493],"category_scores_gemma":[0.005233931,0.0005453692,0.001921957,0.0005523736,0.0009739414,0.0008053493,0.0002275607,0.001829132,0.0005400682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005002667,"about_ca_system_score_gemma":0.0008400228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003017724,"about_ca_topic_score_gemma":0.0002690245,"domain_scores_codex":[0.9968644,0.001883077,0.0003181668,0.0003295497,0.0004572507,0.0001476009],"domain_scores_gemma":[0.9955534,0.001677561,0.001378034,0.0003697218,0.0005118126,0.0005094411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8972669,0.009659428,0.00206657,0.001696446,0.002510755,0.00007062575,0.00008053854,0.0003239546,0.01456858,0.0001044451,0.0007438262,0.07090791],"study_design_scores_gemma":[0.7174461,0.2557912,0.01386493,0.0001639593,0.002867608,0.0002021646,0.00003108119,0.0008362127,0.005972556,0.0001400817,0.002638719,0.00004539778],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9549071,0.03269159,0.003785758,0.0007652676,0.0004261962,0.003253609,0.001605504,0.0002408485,0.002323998],"genre_scores_gemma":[0.9828078,0.008208052,0.002392047,0.000896031,0.0008400765,0.00220876,0.001628937,0.00004577691,0.0009725945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006634142,"threshold_uncertainty_score":0.03508514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02345223868321901,"score_gpt":0.3236762313714055,"score_spread":0.3002239926881865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}