{"id":"W1831026143","doi":"","title":"Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice.","year":2001,"lang":"en","type":"article","venue":"PubMed","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Wortmannin; Gemcitabine; Protein kinase B; Pancreatic cancer; Apoptosis; PI3K/AKT/mTOR pathway; Medicine; Cancer research; Internal medicine; Pharmacology; Endocrinology; Cancer; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002597363,0.001061825,0.0005416803,0.0006262822,0.0002135065,0.0002835542,0.0003286137,0.0003812256,0.001257358],"category_scores_gemma":[0.0001102247,0.0003582928,0.0004086971,0.0003663742,0.0002496754,0.000304597,0.0001652549,0.001245278,0.0004349721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000445086,"about_ca_system_score_gemma":0.0003097606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006271336,"about_ca_topic_score_gemma":0.001699802,"domain_scores_codex":[0.9997831,0.00003743527,0.0000285618,0.00004764458,0.00005269531,0.00005055388],"domain_scores_gemma":[0.9998766,0.00001967978,0.00004207748,0.00001833825,0.000008412431,0.00003481865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003233456,0.0001759496,0.0001474146,0.00005069634,0.000009336829,0.00003488305,0.00001224034,0.00008679778,0.9975209,0.00007124534,0.0001390991,0.001428089],"study_design_scores_gemma":[0.0000946564,0.001595297,0.003022772,0.000008384841,0.00002669326,0.000243526,0.00001284789,0.001317067,0.9915614,0.00003999203,0.002071767,0.000005688534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830089,0.005714362,0.005229116,0.0003642098,0.0002148338,0.0001668524,0.00212992,0.0004862836,0.002685485],"genre_scores_gemma":[0.981033,0.004426526,0.007744967,0.0001084666,0.00005052602,0.0002371817,0.002725447,0.00006139381,0.003612568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001257358,"threshold_uncertainty_score":0.0042063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01691365730361794,"score_gpt":0.2532165656321438,"score_spread":0.2363029083285259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}