{"id":"W1831026143","doi":"","title":"Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice.","year":2001,"lang":"en","type":"article","venue":"PubMed","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Wortmannin; Gemcitabine; Protein kinase B; Pancreatic cancer; Apoptosis; PI3K/AKT/mTOR pathway; Medicine; Cancer research; Internal medicine; Pharmacology; Endocrinology; Cancer; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003608525,0.0001994469,0.0002347804,0.000127162,0.00006263846,0.000037064,0.0001217641,0.0001381532,0.00001445886],"category_scores_gemma":[0.00007475797,0.000204435,0.00004204861,0.0002954095,0.00008111705,0.00001600679,0.00009041488,0.0001605287,9.938865e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001112962,"about_ca_system_score_gemma":0.00004762191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009348497,"about_ca_topic_score_gemma":0.001977481,"domain_scores_codex":[0.9985675,0.00007334667,0.0002740119,0.0004750017,0.0001490099,0.0004611328],"domain_scores_gemma":[0.9995046,0.00001619946,0.0001202853,0.0002465633,0.0000446466,0.0000677425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001390453,0.0001673016,0.5546414,0.00005102071,0.00002587501,0.00001533518,0.0001173105,0.0001092533,0.4276034,0.000008965583,0.00003576928,0.01708529],"study_design_scores_gemma":[0.0008735175,0.00004733465,0.7347003,0.00005058626,0.00001267107,0.000006275518,0.00001348272,0.00005281929,0.263167,0.00002303881,0.0008491835,0.0002037691],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938243,0.004652184,0.00002716528,0.000141594,0.0001498899,0.0008672251,0.00001040258,0.00001701093,0.0003102338],"genre_scores_gemma":[0.9976819,0.0004107401,0.00003503247,0.00006559698,0.0001092416,0.001252047,0.00003473466,0.0000260378,0.0003847321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1800589,"threshold_uncertainty_score":0.8336619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01691365730361794,"score_gpt":0.2532165656321438,"score_spread":0.2363029083285259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}