{"id":"W1831037246","doi":"10.1124/mol.59.3.636","title":"Glucuronidation of the Nonsteroidal Antiestrogen EM-652 (SCH 57068), by Human and Monkey Steroid Conjugating UDP-Glucuronosyltransferase Enzymes","year":2001,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"","keywords":"Glucuronidation; Microsome; Glucuronide; Enzyme; Glucuronosyltransferase; Metabolite; In vivo; Biology; Metabolism; Steroid; Chemistry; Biochemistry; Internal medicine; Endocrinology; Hormone; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001698521,0.0002607251,0.0002429845,0.00005037708,0.000188443,0.0000240427,0.0002765385,0.0002486776,0.00004939315],"category_scores_gemma":[0.00001826155,0.000221369,0.0001304429,0.0001310665,0.0002570897,0.000009991528,0.0001608338,0.0002457207,0.000003785812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001239032,"about_ca_system_score_gemma":0.00005333069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002415962,"about_ca_topic_score_gemma":0.000004974857,"domain_scores_codex":[0.9983876,0.0003315255,0.0003379194,0.0004196636,0.0001543231,0.0003689288],"domain_scores_gemma":[0.9993758,0.00001924122,0.0001497948,0.0002716965,0.00006881388,0.0001146154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000105606,0.0001082764,0.005208098,0.00002558825,0.0001954613,0.00002081061,0.00007819045,0.00007522431,0.9917129,0.00006776677,0.001003058,0.00139905],"study_design_scores_gemma":[0.001831065,0.0004887723,0.000626492,0.00001342392,0.0001417655,0.0001032452,0.00005432196,0.0001236681,0.991522,0.00002010284,0.004853368,0.000221746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992299,0.005664943,0.0007032937,0.0002510865,0.0002158693,0.0004642382,0.0000300979,0.00001863633,0.0003528759],"genre_scores_gemma":[0.9984691,0.0004170636,0.00008384285,0.0005873312,0.00008107923,0.00003128486,0.0001140975,0.00003980386,0.0001764222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006170116,"threshold_uncertainty_score":0.9027168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003322396412704606,"score_gpt":0.2400679517884961,"score_spread":0.2367455553757915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}