{"id":"W1831196039","doi":"10.1007/s10549-015-3612-z","title":"Predictive value and clinical utility of centrally assessed ER, PgR, and Ki-67 to select adjuvant endocrine therapy for premenopausal women with hormone receptor-positive, HER2-negative early breast cancer: TEXT and SOFT trials","year":2015,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Health Services","funders":"National Cancer Institute; Susan G. Komen for the Cure; Pfizer; Ipsen Fund; Canadian Cancer Society Research Institute; Ipsen; National Institute for Health and Care Research; Cancer Research UK; National Health and Medical Research Council; Breast Cancer Research Foundation; Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung; Oncosuisse","keywords":"Exemestane; Breast cancer; Medicine; Tamoxifen; Internal medicine; Progesterone receptor; Oncology; Estrogen receptor; Population; Cancer; Hormone receptor; Gynecology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003731598,0.00104502,0.001420094,0.0008116257,0.0003541435,0.001285294,0.0006774738,0.001377577,0.002390173],"category_scores_gemma":[0.01197491,0.0004041175,0.001459283,0.0006735891,0.0008463431,0.001293095,0.0005700261,0.0009632165,0.0004052495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004221057,"about_ca_system_score_gemma":0.0004017249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001048658,"about_ca_topic_score_gemma":0.001650444,"domain_scores_codex":[0.9987128,0.0008017679,0.000101889,0.0001628715,0.0001432468,0.00007741823],"domain_scores_gemma":[0.9909383,0.006121317,0.001267545,0.0006587478,0.0003975609,0.0006165483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.443147,0.002561356,0.469821,0.0006188863,0.005192552,0.0001507939,0.0002524664,0.001570575,0.003812382,0.0002030981,0.0007684456,0.07190144],"study_design_scores_gemma":[0.05691485,0.07357643,0.8362939,0.000277754,0.01636065,0.0004618321,0.0003963411,0.006881356,0.004234958,0.001715414,0.002739823,0.0001466286],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918334,0.005026297,0.0002564531,0.0002508444,0.00009591876,0.0001348181,0.0004920968,0.00001815422,0.001892035],"genre_scores_gemma":[0.9979595,0.0006740216,0.0001799947,0.0001379587,0.0001485937,0.00003495918,0.0004481838,0.000005136542,0.0004117213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003731598,"threshold_uncertainty_score":0.0197348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06265246098170117,"score_gpt":0.3926188715416153,"score_spread":0.3299664105599141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}