{"id":"W183120660","doi":"10.3233/jad-2011-110353","title":"Fyn, a Potential Target for Alzheimer's Disease","year":2011,"lang":"en","type":"review","venue":"Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"FYN; Neuroscience; Neurotoxicity; Pathogenesis; Synaptic plasticity; Alzheimer's disease; Dementia; Src family kinase; Mechanism (biology); Phosphorylation; Tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; Biology; Disease; Cell biology; Signal transduction; Medicine; Immunology; Pathology; Biochemistry; Receptor; Internal medicine; Philosophy; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000412693,0.0009089438,0.001287263,0.001442636,0.0002931458,0.0006252391,0.0006945272,0.001098071,0.003056474],"category_scores_gemma":[0.0002521367,0.0001915831,0.0003409069,0.001035025,0.0003084274,0.001049341,0.0005099796,0.001341168,0.002621796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005065019,"about_ca_system_score_gemma":0.0006925486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001027976,"about_ca_topic_score_gemma":0.001761107,"domain_scores_codex":[0.9999183,0.00001160538,0.000009481721,0.00001484483,0.00003298842,0.00001264829],"domain_scores_gemma":[0.9999337,0.00001613501,0.00001254562,0.000002133517,0.00002067573,0.00001488669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001256538,0.00009891684,0.000137552,0.009290924,0.00006632892,0.0004403049,0.00005478833,0.0002741665,0.008033995,0.003005628,0.0313336,0.9471381],"study_design_scores_gemma":[0.00004637768,0.0001340402,0.0009183898,0.001611557,0.00008320998,0.001893584,0.00004592058,0.00009670909,0.00146135,0.001977332,0.9917155,0.00001620117],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002201499,0.9983019,0.0001346215,0.0001829442,0.0001448433,0.000005271968,0.00001637589,0.000006809874,0.0009872137],"genre_scores_gemma":[0.001320095,0.9966319,0.0002480489,0.0001446865,0.0001142377,0.00000891843,0.00004862566,0.000001163793,0.001482307],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003056474,"threshold_uncertainty_score":0.01022488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09120438496826072,"score_gpt":0.3801429406265824,"score_spread":0.2889385556583217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}