{"id":"W1831550187","doi":"10.1038/srep15756","title":"High efficacy vasopermeability drug candidates identified by screening in an ex ovo chorioallantoic membrane model","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Eli Lilly and Company","keywords":"In ovo; Chorioallantoic membrane; Drug; Medicine; Biology; Computational biology; Pharmacology; Genetics; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005497388,0.0004993758,0.0003536101,0.0003960721,0.0001130139,0.0002942468,0.0001700649,0.0002617313,0.001358275],"category_scores_gemma":[0.0002681107,0.0001435347,0.0002412836,0.0001581654,0.000218423,0.0002479018,0.0001555064,0.0005354148,0.0002314219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002033436,"about_ca_system_score_gemma":0.0002008545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005015372,"about_ca_topic_score_gemma":0.0009629316,"domain_scores_codex":[0.999796,0.00006187322,0.00001853108,0.00003253644,0.00005229388,0.00003879327],"domain_scores_gemma":[0.9997699,0.00008957827,0.00005498321,0.00002529902,0.00003135339,0.0000289645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001240215,0.0001114911,0.0001583321,0.0000288572,0.000003785942,0.00003378907,0.000009994205,0.00007287542,0.9981487,0.00004235772,0.00002451827,0.001241272],"study_design_scores_gemma":[0.00002140393,0.003309453,0.001852321,0.000004569881,0.00002415119,0.0001341043,0.00001874591,0.0005060771,0.993017,0.0000165855,0.001092076,0.000003570289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862627,0.00165361,0.009161558,0.00009837487,0.00002960975,0.000294988,0.0004218508,0.00008872346,0.001988639],"genre_scores_gemma":[0.9803079,0.002159828,0.01300155,0.00005358371,0.00001277344,0.0001787369,0.0006958012,0.00002050647,0.003569353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001358275,"threshold_uncertainty_score":0.004543841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02784973245937697,"score_gpt":0.2666338708307057,"score_spread":0.2387841383713287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}