{"id":"W1831550187","doi":"10.1038/srep15756","title":"High efficacy vasopermeability drug candidates identified by screening in an ex ovo chorioallantoic membrane model","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Eli Lilly and Company","keywords":"In ovo; Chorioallantoic membrane; Drug; Medicine; Biology; Computational biology; Pharmacology; Genetics; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004613825,0.000291047,0.0005205953,0.000228582,0.0002958415,0.0002315765,0.0003665384,0.0001977544,0.0002169252],"category_scores_gemma":[0.0004472313,0.0002509811,0.000101265,0.000467708,0.0004865822,0.0006043201,0.0001537834,0.0002898148,0.000168085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008001002,"about_ca_system_score_gemma":0.000260145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001397591,"about_ca_topic_score_gemma":0.000550938,"domain_scores_codex":[0.9959999,0.0004978348,0.000924558,0.001743643,0.0002126625,0.0006213672],"domain_scores_gemma":[0.9972801,0.00005297336,0.0003662301,0.001833806,0.0003397664,0.0001270752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001279888,0.0006121756,0.1464256,0.00006888733,0.00009748102,0.0001879791,0.005051733,0.002461342,0.7816464,0.00009345903,0.06148224,0.001744711],"study_design_scores_gemma":[0.004800318,0.0001857423,0.04062499,0.000506195,0.0001347697,0.001022587,0.001635937,0.0006400367,0.9164805,0.01255617,0.01956389,0.00184879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840219,0.005047536,0.0001793956,0.0001100933,0.008580645,0.0007025427,0.00002373368,0.000131165,0.00120296],"genre_scores_gemma":[0.9792598,0.00000439609,0.0001645477,0.00001350093,0.00005006681,0.00003728271,0.0007412583,0.00002536873,0.0197038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1348342,"threshold_uncertainty_score":0.9999942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02784973245937697,"score_gpt":0.2666338708307057,"score_spread":0.2387841383713287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}