{"id":"W1831954784","doi":"10.1002/psc.2492","title":"Rapid high‐yield <i>N</i>‐acylation of aminothiols: <i>N</i>‐acetylglutathione and <i>N</i>‐acetylhomocysteine and their thiol p<i>K</i><sub>a</sub> values","year":2013,"lang":"en","type":"article","venue":"Journal of Peptide Science","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; Espace pour la vie","funders":"Concordia University","keywords":"Chemistry; Dithiothreitol; Reagent; Aqueous solution; Thiol; Acylation; Titration; Chromatography; Yield (engineering); Cationic polymerization; Tris; Ion exchange; Acetylation; Cysteine; Acetone; Nuclear chemistry; Organic chemistry; Biochemistry; Ion; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005349049,0.0007451614,0.0006475043,0.0002179277,0.0003851156,0.0002738164,0.0005996664,0.0004026313,0.001429785],"category_scores_gemma":[0.0003863589,0.0003353003,0.0004185945,0.0002985747,0.0002348754,0.0003260681,0.0005533498,0.001306588,0.001245557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003985097,"about_ca_system_score_gemma":0.0004253791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008215401,"about_ca_topic_score_gemma":0.002180894,"domain_scores_codex":[0.9996719,0.00005752327,0.00002886282,0.00008357048,0.00009911755,0.00005896786],"domain_scores_gemma":[0.9997754,0.00003521614,0.00004202293,0.00005420846,0.00006016821,0.0000330331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002836803,0.00001353328,0.00004263479,0.00005537605,0.000009510451,0.00002987191,0.00002398962,0.00003915259,0.9982769,0.0001060556,0.0001335839,0.001241002],"study_design_scores_gemma":[0.000006234809,0.00004552172,0.0002361311,0.000003839345,0.000008203171,0.00009709088,0.0000108631,0.0002847529,0.9957769,0.00005094371,0.003471381,0.000008125406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7538803,0.004953246,0.2239299,0.0004855397,0.0003394048,0.0007271998,0.002631191,0.002400955,0.01065228],"genre_scores_gemma":[0.8538665,0.00679235,0.1175947,0.0002563866,0.0000475781,0.000709083,0.005961073,0.0006624469,0.01410988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001429785,"threshold_uncertainty_score":0.004783154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01032088547677024,"score_gpt":0.2192709382497378,"score_spread":0.2089500527729676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}