{"id":"W1831954784","doi":"10.1002/psc.2492","title":"Rapid high‐yield <i>N</i>‐acylation of aminothiols: <i>N</i>‐acetylglutathione and <i>N</i>‐acetylhomocysteine and their thiol p<i>K</i><sub>a</sub> values","year":2013,"lang":"en","type":"article","venue":"Journal of Peptide Science","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; Espace pour la vie","funders":"Concordia University","keywords":"Chemistry; Dithiothreitol; Reagent; Aqueous solution; Thiol; Acylation; Titration; Chromatography; Yield (engineering); Cationic polymerization; Tris; Ion exchange; Acetylation; Cysteine; Acetone; Nuclear chemistry; Organic chemistry; Biochemistry; Ion; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001857588,0.0002721565,0.0004550844,0.0002348385,0.0002158178,0.0000865779,0.0005069606,0.0001798013,0.00001081964],"category_scores_gemma":[0.0008956226,0.0002044422,0.0001104856,0.0003404568,0.00129471,0.00009756786,0.0003309258,0.0002988329,0.000003839369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000269839,"about_ca_system_score_gemma":0.000213314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002004744,"about_ca_topic_score_gemma":0.000007369126,"domain_scores_codex":[0.9978809,0.0001587335,0.0007528207,0.0004403818,0.0003715658,0.0003956322],"domain_scores_gemma":[0.9976404,0.0002170431,0.0007809346,0.0003982743,0.000732287,0.0002311007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006193273,0.00004791107,0.00201589,0.0000244424,0.00003986655,0.000001877822,0.0002508728,0.00002489002,0.9867283,0.00008294049,0.0006717007,0.01004937],"study_design_scores_gemma":[0.0007348392,0.001135197,0.01321961,0.00009456089,0.00002501595,0.0004081764,0.0003670663,0.0001152933,0.9818884,0.001170305,0.0006085568,0.000232992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934669,0.004122052,0.001011838,0.000457049,0.0003972182,0.0002381958,0.00001120033,0.000008851797,0.0002867295],"genre_scores_gemma":[0.9930833,0.003032301,0.003045477,0.0004549348,0.0003274028,0.000006359042,0.000004104843,0.00001973312,0.00002636838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01120372,"threshold_uncertainty_score":0.8336912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01032088547677024,"score_gpt":0.2192709382497378,"score_spread":0.2089500527729676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}