{"id":"W1832018093","doi":"10.1194/jlr.m400477-jlr200","title":"Structural modification of plasma HDL by phospholipids promotes efficient ABCA1-mediated cholesterol release","year":2005,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"Canadian Institutes of Health Research; Heart And Stroke Foundation Of Quebec; McGill University; Heart and Stroke Foundation of Canada","keywords":"Phospholipid; ABCA1; Efflux; Cholesterol; Chemistry; Tangier disease; Apolipoprotein B; Phosphatidylcholine; Lysophosphatidylcholine; Reverse cholesterol transport; Vesicle; Biochemistry; Lipoprotein; Membrane; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002251866,0.0002089081,0.0006277605,0.0006022835,0.0001174954,0.0000513022,0.0003692565,0.0001877903,0.0001895489],"category_scores_gemma":[0.0008316888,0.0001505185,0.0002242069,0.0006437475,0.0002969764,0.0002035692,0.00008211251,0.001282409,0.00005541434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000273292,"about_ca_system_score_gemma":0.0003622008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005610102,"about_ca_topic_score_gemma":0.000003587886,"domain_scores_codex":[0.9958342,0.0002968555,0.00111178,0.0002680036,0.001939929,0.000549229],"domain_scores_gemma":[0.9968477,0.0002262893,0.0005068058,0.0004321746,0.001442969,0.0005440343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003247349,0.001734007,0.00513257,0.0004136114,0.000243658,0.00002451296,0.002481949,0.0006994035,0.8883023,0.00008396932,0.01439062,0.08324607],"study_design_scores_gemma":[0.02158164,0.003374903,0.1695647,0.001189254,0.000253839,0.001144042,0.001378379,0.03834316,0.6372125,0.00003742747,0.1253851,0.0005350714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925538,0.0009426133,0.00003437363,0.00502804,0.0004340308,0.000439245,0.00002740671,0.00001680666,0.0005236327],"genre_scores_gemma":[0.9958408,0.0002646829,0.0005092588,0.0001112467,0.002325067,0.000008055105,0.00001924221,0.00003763926,0.0008840081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2510898,"threshold_uncertainty_score":0.6137965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0511621871249741,"score_gpt":0.3592327414439246,"score_spread":0.3080705543189505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}