{"id":"W1832328879","doi":"10.4049/jimmunol.165.6.3073","title":"Thymic Selection Generates T Cells Expressing Self-Reactive TCRs in the Absence of CD45","year":2000,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aptose Biosciences (Canada); McGill University","funders":"Medical Research Council; Medical Research Council Canada; University of Toronto","keywords":"T-cell receptor; Avidity; CD8; Central tolerance; Biology; Cell biology; Major histocompatibility complex; Negative selection; Molecular biology; Thymocyte; Antigen; Chemistry; T cell; Immunology; Immune system; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001784897,0.0003367052,0.0002593708,0.0003004628,0.0001466365,0.0004611625,0.0002878068,0.0002194542,0.001372673],"category_scores_gemma":[0.0001698168,0.0001997946,0.0001838282,0.0001740844,0.0001839132,0.0001523892,0.0004020877,0.0005556804,0.0006062155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000111252,"about_ca_system_score_gemma":0.0001176867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000146395,"about_ca_topic_score_gemma":0.0003443208,"domain_scores_codex":[0.9996386,0.00004462498,0.00004009078,0.00007183705,0.0001079157,0.00009697479],"domain_scores_gemma":[0.9996443,0.00006448914,0.00009899417,0.00005720367,0.00002776176,0.0001072696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003548529,0.00001240513,0.0003323492,0.00001199298,0.000002705494,0.00004826242,0.000008963892,0.00002251177,0.9986513,0.0000677254,0.00001482863,0.0007913769],"study_design_scores_gemma":[0.00003578845,0.0002250871,0.005557023,0.00001051055,0.00002921213,0.001110962,0.00002904138,0.001173004,0.9890853,0.00008751625,0.002650157,0.000006372225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919625,0.0006492541,0.005252858,0.00004297002,0.00001973626,0.00004048627,0.0001868474,0.0001202653,0.001725202],"genre_scores_gemma":[0.9949307,0.0003698276,0.002314209,0.00005275692,0.00001470711,0.00003400216,0.0003979595,0.000052647,0.001833122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001372673,"threshold_uncertainty_score":0.004592001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00805181408113155,"score_gpt":0.2220304185581066,"score_spread":0.213978604476975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}