{"id":"W1834366147","doi":"10.1016/j.urolonc.2014.06.018","title":"GnRH antagonist associates with less adiposity and reduced characteristics of metabolic syndrome and atherosclerosis compared with orchiectomy and GnRH agonist in a preclinical mouse model","year":2014,"lang":"en","type":"article","venue":"Urologic Oncology Seminars and Original Investigations","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre; Sunnybrook Health Science Centre; Health Sciences Centre; Thrombosis and Atherosclerosis Research Institute; University of Toronto; McMaster University","funders":"","keywords":"Orchiectomy; Medicine; Internal medicine; Endocrinology; Testosterone (patch); Androgen deprivation therapy; Agonist; Gonadotropin-releasing hormone agonist; Hormone; Luteinizing hormone; Gonadotropin-releasing hormone; Receptor; Prostate cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003846832,0.0009853147,0.0007601076,0.001297084,0.0003682014,0.0007208494,0.0004830318,0.0007311692,0.003610045],"category_scores_gemma":[0.0002560863,0.0004798769,0.0008541307,0.0004890348,0.000678406,0.0006609352,0.0002981795,0.002377117,0.0005562991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003416134,"about_ca_system_score_gemma":0.0005823708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007957626,"about_ca_topic_score_gemma":0.001560992,"domain_scores_codex":[0.9996477,0.00005189101,0.00003602416,0.00009668609,0.0000906865,0.00007697226],"domain_scores_gemma":[0.9992889,0.00004675338,0.0002673549,0.00007758148,0.0000522273,0.0002671902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009502734,0.001828939,0.002313573,0.0002134472,0.0001002766,0.000433483,0.0000536294,0.0001468868,0.9802469,0.0002469374,0.0004669508,0.004446203],"study_design_scores_gemma":[0.001489203,0.02154179,0.05208982,0.0001250005,0.0008160158,0.002300446,0.0005498896,0.001398687,0.908231,0.0005858898,0.01078894,0.00008332089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914067,0.002049434,0.002278048,0.0006156003,0.0002656265,0.000071266,0.001771267,0.0001803732,0.001361642],"genre_scores_gemma":[0.972513,0.004797591,0.004428602,0.0007428283,0.0001925836,0.0003900425,0.003142127,0.0001752882,0.01361807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003610045,"threshold_uncertainty_score":0.0120768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04373456151893877,"score_gpt":0.3032731184062592,"score_spread":0.2595385568873204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}