{"id":"W1834418587","doi":"10.1073/pnas.0307150101","title":"Cu(I)-catalyzed direct addition and asymmetric addition of terminal alkynes to imines","year":2004,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":202,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Science Foundation","keywords":"Catalysis; Yield (engineering); Enantiomeric excess; Toluene; Chemistry; Enantiomer; Absolute configuration; Combinatorial chemistry; Enantioselective synthesis; Stereochemistry; Organic chemistry; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003036799,0.0008724615,0.0005657589,0.000379528,0.0002461739,0.0004104009,0.001050506,0.0005703448,0.0008242355],"category_scores_gemma":[0.0003703767,0.0004715898,0.0003280903,0.0002622448,0.0003164173,0.0005798452,0.0005899182,0.0008831709,0.0006183839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004648771,"about_ca_system_score_gemma":0.0004397517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006217367,"about_ca_topic_score_gemma":0.0012378,"domain_scores_codex":[0.9996771,0.00004251265,0.00003115956,0.00007548764,0.00006696335,0.0001068962],"domain_scores_gemma":[0.9998618,0.00001756745,0.00003430066,0.00002246424,0.0000280511,0.00003577104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002096253,0.0001296594,0.000218287,0.0004210495,0.00003329037,0.0006438979,0.0001105572,0.0006197635,0.9743854,0.002036819,0.0006203799,0.02057112],"study_design_scores_gemma":[0.00002552596,0.0001473844,0.0001582868,0.000004911009,0.00001186471,0.0002649273,0.000008386685,0.0005891622,0.996119,0.00005908262,0.002601528,0.000009945122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8916029,0.005277239,0.07679389,0.0003363697,0.0003907675,0.0006368273,0.000956183,0.000820066,0.02318571],"genre_scores_gemma":[0.9681627,0.002457145,0.02150364,0.00007094322,0.00004214337,0.0001769793,0.0004617955,0.00004746031,0.007077236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001050506,"threshold_uncertainty_score":0.003372908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02414470062592028,"score_gpt":0.2732539495442012,"score_spread":0.2491092489182809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}