{"id":"W1835102699","doi":"10.1016/j.metabol.2015.08.007","title":"The contribution of PCSK9 levels to the phenotypic severity of familial hypercholesterolemia is independent of LDL receptor genotype","year":2015,"lang":"en","type":"article","venue":"Metabolism","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Institut sur la Nutrition et les Aliments Fonctionnels; Université Laval","keywords":"PCSK9; LDL receptor; Kexin; Familial hypercholesterolemia; Internal medicine; Apolipoprotein B; Endocrinology; Genotype; Medicine; Lipoprotein; Cholesterol; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002361955,0.0001269315,0.000566789,0.00004678149,0.00006365243,0.000006397896,0.0002238266,0.0001115869,0.00002452088],"category_scores_gemma":[0.0004123489,0.00006990567,0.0002281769,0.0002477558,0.0001052681,0.00004255018,0.00009980087,0.0002056865,0.0000196447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005214984,"about_ca_system_score_gemma":0.0003316552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001072807,"about_ca_topic_score_gemma":0.0000856535,"domain_scores_codex":[0.9979997,0.0002557249,0.0004840425,0.00017936,0.0008520489,0.0002290936],"domain_scores_gemma":[0.998093,0.00004236751,0.000192359,0.000781383,0.0007421196,0.0001487458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.005970186,0.0009260743,0.02091967,0.0005662225,0.002709419,0.000006324638,0.02253933,0.0001394095,0.2276776,0.01018258,0.01100537,0.6973578],"study_design_scores_gemma":[0.003978729,0.0002847286,0.5285839,0.00008182506,0.0004829204,0.00001412917,0.0008008737,0.00003398841,0.1697827,0.0004382297,0.2953721,0.000145871],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903976,0.005337951,0.0009473748,0.001558498,0.0005629742,0.000860935,0.00009137391,0.000009964841,0.0002333584],"genre_scores_gemma":[0.998411,0.0001608495,0.0003352792,0.0004766074,0.0004112748,0.00002371673,0.000008313816,0.00001417799,0.0001587698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6972119,"threshold_uncertainty_score":0.285067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03012448865358191,"score_gpt":0.279144346671149,"score_spread":0.249019858017567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}