{"id":"W1836182162","doi":"10.1212/wnl.82.10_supplement.p1.227","title":"Randomized Trial of Minocycline for Clinically Isolated Syndrome and Early Single Relapse Multiple Sclerosis: Study Design, Participant Characteristics, and Recruitment Challenges (P1.227)","year":2014,"lang":"en","type":"article","venue":"Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Dalhousie University; University of Alberta; Burnaby Hospital; University of Manitoba; Ottawa Hospital; University of British Columbia; Hôpital Notre-Dame; Clinique Neuro-Outaouais; University of Calgary","funders":"","keywords":"Minocycline; Multiple sclerosis; Randomized controlled trial; Medicine; Clinically isolated syndrome; Physical therapy; Physical medicine and rehabilitation; Internal medicine; Oncology; Immunology; Biology; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003857417,0.002274944,0.004095652,0.0004576672,0.0008269681,0.001195697,0.001061304,0.0031669,0.008580734],"category_scores_gemma":[0.004050299,0.0008497406,0.001512593,0.0004505377,0.001461699,0.0009664536,0.0005826567,0.002784048,0.00150782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00133506,"about_ca_system_score_gemma":0.00428453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002828693,"about_ca_topic_score_gemma":0.007568229,"domain_scores_codex":[0.9977659,0.001407221,0.0001201631,0.0002256388,0.0001983747,0.0002827287],"domain_scores_gemma":[0.9979879,0.0004657055,0.0004589517,0.0001318316,0.0002349616,0.000720649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.98452,0.005089198,0.0002807352,0.0004464333,0.0003701788,0.000026172,0.00003147567,0.0001056238,0.0009861444,0.0001019391,0.0007343239,0.007307955],"study_design_scores_gemma":[0.968662,0.03017693,0.0003834145,0.00001752038,0.0001161655,0.00001357741,0.00000643197,0.0001106752,0.0001146244,0.0000561791,0.0003359613,0.000006546531],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9018718,0.005860151,0.002458578,0.002368593,0.001931184,0.07737285,0.002719828,0.000376776,0.005040258],"genre_scores_gemma":[0.8974992,0.0024596,0.00670143,0.002875772,0.001149808,0.08002857,0.001376498,0.00004108572,0.007867989],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.008580734,"threshold_uncertainty_score":0.02870548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3636061408841462,"score_gpt":0.3784735990902781,"score_spread":0.01486745820613189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}