{"id":"W1837885345","doi":"10.1002/ana.24406","title":"Cerebrovascular and blood–brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology","year":2015,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":287,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; National Institute for Health and Care Research; Huntington's Disease Society of America","keywords":"Huntington's disease; Pathophysiology; Blood–brain barrier; Huntingtin; Pathology; Striatum; Neuroscience; Medicine; Central nervous system; Biology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001663426,0.0001685665,0.000259862,0.0001508276,0.00006581498,0.00001266013,0.000249258,0.00006737949,0.000009151096],"category_scores_gemma":[0.002094827,0.0001714052,0.000105538,0.0001693429,0.0001995225,0.00008966515,0.0001625665,0.00009463238,0.000004415203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001643786,"about_ca_system_score_gemma":0.00009553781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005061536,"about_ca_topic_score_gemma":0.000002907316,"domain_scores_codex":[0.9981174,0.0004365092,0.000292805,0.0006376744,0.0001181635,0.0003973802],"domain_scores_gemma":[0.9988587,0.000259196,0.0001302902,0.0003438683,0.0001280853,0.0002797854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003103935,0.000377536,0.02169207,0.00003797629,0.00001128689,0.00002174363,0.00006251858,0.0007460276,0.9736627,0.001089534,0.001604988,0.0003832707],"study_design_scores_gemma":[0.002577318,0.001814847,0.5325848,0.000006865158,0.00005990493,0.00003168336,0.00001008042,0.0009427235,0.4387596,0.02127387,0.00161055,0.0003277198],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865441,0.0001626336,0.00006449117,0.01229002,0.0001399567,0.0005362805,0.0002154756,0.00002267477,0.00002432248],"genre_scores_gemma":[0.9879554,0.00009569347,0.00003802885,0.01163711,0.00006002407,0.0001412035,0.00001155226,0.00002471776,0.00003630338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.534903,"threshold_uncertainty_score":0.6989701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06318386891235114,"score_gpt":0.3251074906650827,"score_spread":0.2619236217527315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}