{"id":"W1838223798","doi":"10.1039/c5sc03705k","title":"Activity modulation and allosteric control of a scaffolded DNAzyme using a dynamic DNA nanostructure","year":2015,"lang":"en","type":"article","venue":"Chemical Science","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kellogg's (Canada)","funders":"National Key Research and Development Program of China; Ministry of Science and Technology of the People's Republic of China; Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Deoxyribozyme; Allosteric regulation; Nanotechnology; DNA; DNA nanotechnology; Chemistry; Rational design; Nanostructure; Materials science; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009315339,0.0001394095,0.0001188277,0.00008248851,0.0000785131,0.0002522134,0.0002852393,0.0002231224,0.0004214979],"category_scores_gemma":[0.0001792565,0.0001084828,0.0001092946,0.00006604547,0.0002526712,0.0001734201,0.0001622315,0.0002906839,0.0001153297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001965863,"about_ca_system_score_gemma":0.00009862005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001765683,"about_ca_topic_score_gemma":0.0003392774,"domain_scores_codex":[0.999925,0.000008503454,0.000005689481,0.0000311884,0.00001943001,0.0000100776],"domain_scores_gemma":[0.9999242,0.00002061792,0.00002260968,0.00001038701,0.000009103721,0.00001314174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001413429,0.00001213848,0.00005339117,0.0000107329,0.000001421735,0.00001481614,0.00001168097,0.0002192142,0.9984618,0.000225525,0.00001284214,0.0009622178],"study_design_scores_gemma":[0.000009724553,0.0001051759,0.0002569178,0.000001458105,0.000004206495,0.0000506182,0.00000628277,0.004188715,0.994405,0.00006211738,0.0009057268,0.000004009646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856499,0.0002844187,0.01220735,0.00009557654,0.00003381937,0.00001614501,0.00003514214,0.0001097522,0.001567818],"genre_scores_gemma":[0.9919021,0.0001146921,0.00707511,0.00003837223,0.000006599477,0.00001347584,0.00002962773,0.00001051028,0.0008096505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004214979,"threshold_uncertainty_score":0.001426399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252506534457561,"score_gpt":0.2818018335603366,"score_spread":0.269276768215761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}