{"id":"W1838530782","doi":"10.1158/1538-7445.am2014-3765","title":"Abstract 3765: Indoleamine 2,3-dioxygenase mediates immune-independent human tumor cell resistance to olaparib, γ radiation, and cisplatin","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"Olaparib; Indoleamine 2,3-dioxygenase; Cancer research; Immune system; Cisplatin; Cancer; Cancer cell; Immunosurveillance; PARP inhibitor; DNA repair; Medicine; Biology; Immunology; Poly ADP ribose polymerase; Internal medicine; Chemotherapy; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009912059,0.0003146992,0.0002368987,0.0001821221,0.000116476,0.0001816842,0.0001922416,0.0001882226,0.002953365],"category_scores_gemma":[0.00007912793,0.00009607713,0.0001916801,0.0001145222,0.0001424286,0.00008681713,0.0001408429,0.0003192353,0.001038796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002364174,"about_ca_system_score_gemma":0.0002052005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001042825,"about_ca_topic_score_gemma":0.000691556,"domain_scores_codex":[0.9999226,0.00001395406,0.000007976924,0.00001416278,0.00001599307,0.00002525383],"domain_scores_gemma":[0.9999212,0.00001730957,0.00001129123,0.00001080257,0.000008651428,0.0000305942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007186643,0.0001394481,0.0004911838,0.00005668717,0.000007586388,0.0001935933,0.00001653942,0.0001138084,0.9957653,0.0001759598,0.0003466368,0.001974631],"study_design_scores_gemma":[0.0002107622,0.002013101,0.02769385,0.00001693569,0.00003292379,0.001021333,0.0000524146,0.002163521,0.9576498,0.0001632013,0.008975141,0.000007082317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883598,0.002557677,0.001415534,0.0001945072,0.00008425122,0.0001117229,0.001525364,0.00009523935,0.005655864],"genre_scores_gemma":[0.9868772,0.0008622964,0.0009756279,0.00007981158,0.00003119071,0.00007984302,0.002914671,0.00001711071,0.008162377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002953365,"threshold_uncertainty_score":0.009880066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04319448803183638,"score_gpt":0.3501078590588598,"score_spread":0.3069133710270234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}