{"id":"W1838575598","doi":"10.1111/j.1471-4159.2011.07486.x","title":"Pituitary adenylate cyclase‐activating polypeptide (PACAP) stimulates the expression and the release of tissue plasminogen activator (tPA) in neuronal cells: involvement of tPA in the neuroprotective effect of PACAP","year":2011,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Langley Research Center; Institut National de la Santé et de la Recherche Médicale; Institut national de la recherche scientifique","keywords":"Tissue plasminogen activator; Adenylate kinase; Plasminogen activator; Activator (genetics); Pituitary adenylate cyclase-activating peptide; Cyclase; Protein kinase A; Chemistry; T-plasminogen activator; Plasminogen activator inhibitor-1; Neurotrophin; Biology; Endocrinology; Internal medicine; Kinase; Molecular biology; Biochemistry; Neuropeptide; Vasoactive intestinal peptide; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008893714,0.0003679282,0.0003262003,0.0002567725,0.0001931316,0.0002782243,0.0001204474,0.0002186974,0.001036738],"category_scores_gemma":[0.0001345499,0.00008800836,0.0002857731,0.000223136,0.000263503,0.0003251223,0.0001932878,0.0005991015,0.0002678784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003692383,"about_ca_system_score_gemma":0.0003459796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001130208,"about_ca_topic_score_gemma":0.001434102,"domain_scores_codex":[0.9999206,0.000008697054,0.000008098293,0.00001642691,0.00002113816,0.00002508494],"domain_scores_gemma":[0.999929,0.00001245029,0.00001446594,0.000007482834,0.00001129008,0.00002540533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006987054,0.00001175717,0.00007539937,0.00005457203,0.000002882906,0.00008802512,0.00001265574,0.00001214718,0.9983938,0.00004831527,0.00002223353,0.001208256],"study_design_scores_gemma":[0.00001748947,0.0002220021,0.007964255,0.00001010448,0.00002454595,0.0005966032,0.00005254078,0.0002864076,0.9884958,0.0001337789,0.002190464,0.000006089675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790012,0.01333463,0.004383657,0.0002760963,0.00009006019,0.00005370201,0.000453101,0.0000724806,0.002335099],"genre_scores_gemma":[0.9842382,0.007674338,0.004628938,0.00007118107,0.00005727545,0.00008437732,0.0004551413,0.00001426689,0.002776399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001130208,"threshold_uncertainty_score":0.003468215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02152067424334863,"score_gpt":0.2426355736424849,"score_spread":0.2211148993991362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}