{"id":"W1839003622","doi":"10.1093/mutage/gev041","title":"Comparison of<i>in vitro</i>and<i>in vivo</i>clastogenic potency based on benchmark dose analysis of flow cytometric micronucleus data","year":2015,"lang":"en","type":"article","venue":"Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"National Institute of Environmental Health Sciences; National Institutes of Health","keywords":"In vivo; Clastogen; Potency; In vitro; Micronucleus; Flow cytometry; Pharmacology; In vitro toxicology; Micronucleus test; Biology; Toxicology; Toxicity; Immunology; Medicine; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005488836,0.0001904918,0.0005689193,0.0008625314,0.00002098775,0.00001121685,0.0003860499,0.0001447987,0.00002878626],"category_scores_gemma":[0.0000955515,0.0001930915,0.0001496941,0.001622493,0.00006553023,0.000005335025,0.000249223,0.00007076361,0.000001027404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000045951,"about_ca_system_score_gemma":0.0001328004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004453478,"about_ca_topic_score_gemma":0.0006612728,"domain_scores_codex":[0.9982995,0.0001245886,0.0005040232,0.0005400068,0.0002812943,0.0002506234],"domain_scores_gemma":[0.9986466,0.00004600688,0.0001747303,0.0009465724,0.00007838506,0.0001077003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004892939,0.0004902722,0.102497,0.00003259218,0.0001933749,0.000006555832,0.0000615445,0.01878831,0.873051,7.529732e-7,0.0001653419,0.004223965],"study_design_scores_gemma":[0.001453907,0.0003442414,0.1169117,0.00001388714,0.0004179787,0.000001282029,0.0001653838,0.08058735,0.7986798,0.000001900761,0.001161326,0.0002612802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965948,0.001391084,0.0009201943,0.00003998512,0.00005659572,0.0001846987,0.0005980709,0.000003564208,0.0002109788],"genre_scores_gemma":[0.9959173,0.00007677685,0.003363586,0.0000776677,0.00002430653,0.00000943447,0.0004788705,0.00001693692,0.00003516181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07437123,"threshold_uncertainty_score":0.7874045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04219497264389981,"score_gpt":0.3244694874395861,"score_spread":0.2822745147956863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}