{"id":"W1839003622","doi":"10.1093/mutage/gev041","title":"Comparison of<i>in vitro</i>and<i>in vivo</i>clastogenic potency based on benchmark dose analysis of flow cytometric micronucleus data","year":2015,"lang":"en","type":"article","venue":"Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"National Institute of Environmental Health Sciences; National Institutes of Health","keywords":"In vivo; Clastogen; Potency; In vitro; Micronucleus; Flow cytometry; Pharmacology; In vitro toxicology; Micronucleus test; Biology; Toxicology; Toxicity; Immunology; Medicine; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00162683,0.0008224346,0.0006266849,0.001853531,0.0002158912,0.0004194505,0.0004821012,0.0006707806,0.001595466],"category_scores_gemma":[0.001862662,0.0002132634,0.0004946551,0.0008007045,0.00040821,0.0003337458,0.0003956037,0.0008287316,0.0003965519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000425817,"about_ca_system_score_gemma":0.0003104033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001066962,"about_ca_topic_score_gemma":0.001175587,"domain_scores_codex":[0.9987703,0.0003562904,0.0001702926,0.0002315743,0.0003774315,0.00009412241],"domain_scores_gemma":[0.9978999,0.0007226425,0.0003894026,0.0003403985,0.0005504295,0.00009732869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002499728,0.0000708338,0.001419384,0.0001630042,0.00004544951,0.00002006144,0.00005052699,0.001522687,0.9906036,0.0001143777,0.00009073174,0.005649211],"study_design_scores_gemma":[0.00000651337,0.0007720724,0.006475389,0.00001266523,0.00004274223,0.00008849262,0.00002872488,0.002297136,0.9894679,0.00007713887,0.0007198164,0.00001148485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9195435,0.00488946,0.06467677,0.0001627891,0.0000888504,0.0004312195,0.004601878,0.0007181049,0.004887395],"genre_scores_gemma":[0.9494393,0.003289715,0.03733311,0.0001960259,0.00003194719,0.0005861272,0.006424549,0.0001386626,0.002560584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001853531,"threshold_uncertainty_score":0.008603632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04219497264389981,"score_gpt":0.3244694874395861,"score_spread":0.2822745147956863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}