{"id":"W1839791560","doi":"10.1158/0008-5472.can-14-2676","title":"Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Ontario Institute for Cancer Research; University of Waterloo","funders":"","keywords":"Myeloid leukemia; Mitochondrion; Stem cell; Leukemia; Progenitor cell; Haematopoiesis; Apoptosis; Biology; Programmed cell death; Cell; Viability assay; Cancer research; Cytotoxicity; Hematopoietic stem cell; Cell biology; Cytotoxic T cell; Myeloid; Biochemistry; Chemistry; Immunology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005729086,0.0001589513,0.0001678717,0.00008669435,0.0001538987,0.00005618142,0.0003088846,0.0001492288,0.00002651665],"category_scores_gemma":[0.0001513739,0.000132817,0.00003906261,0.0003237416,0.0001417239,0.000008640289,0.0001447746,0.0003911924,0.00002786494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002130987,"about_ca_system_score_gemma":0.002364376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001134103,"about_ca_topic_score_gemma":0.0002562935,"domain_scores_codex":[0.9981237,0.0001814696,0.0001436304,0.0005041974,0.0004654464,0.0005815296],"domain_scores_gemma":[0.9986134,0.00002160308,0.00005414543,0.0003179148,0.0007190786,0.0002738513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003304283,0.00002929136,0.0007349651,0.00002334069,0.00003800169,0.00000217013,0.0004514375,0.0002616016,0.9160029,0.00002796973,0.08056176,0.001536147],"study_design_scores_gemma":[0.001127804,0.0003379615,0.0004164432,0.00002274293,0.00001276434,0.000005200998,0.0007289191,0.0000192794,0.7337359,0.00006836149,0.2633044,0.0002202163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813374,0.010953,0.0002069507,0.0001273748,0.0005374351,0.0003690385,0.000019718,0.00001627874,0.006432816],"genre_scores_gemma":[0.9881115,0.001284917,0.0008761939,0.0001144141,0.003504984,0.0002993129,0.00004911696,0.00004822296,0.005711339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1827427,"threshold_uncertainty_score":0.5416121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05337226525922852,"score_gpt":0.3533256239545401,"score_spread":0.2999533586953116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}