{"id":"W1840818938","doi":"10.1080/15384101.2014.998056","title":"Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition","year":2015,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kootenay Association for Science & Technology","funders":"","keywords":"Transactivation; Isothermal titration calorimetry; Circular dichroism; Biology; Mdm2; Biophysics; Mutagenesis; Phosphorylation; Binding site; Computational biology; Plasma protein binding; Biochemistry; Transcription factor; Cell biology; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009515617,0.0001042371,0.000193555,0.0001086951,0.0000148081,0.000003823009,0.00005198723,0.0001176702,0.00008059985],"category_scores_gemma":[0.00003390231,0.0001034727,0.00005370857,0.0002688479,0.00005652747,0.00008023213,0.000007270706,0.0001699238,0.00001705214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001407113,"about_ca_system_score_gemma":0.0001483785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002154423,"about_ca_topic_score_gemma":0.00003950181,"domain_scores_codex":[0.9991463,0.00003885312,0.0002473189,0.0001872698,0.000225379,0.0001548666],"domain_scores_gemma":[0.9995049,0.00001455968,0.00008965848,0.0001774935,0.0001103263,0.0001030479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005416168,0.00005665335,0.001523226,0.0001106248,0.0000204421,0.00003252169,0.001772272,0.0009130397,0.9827916,0.00002334732,0.0002570257,0.01195764],"study_design_scores_gemma":[0.007281367,0.000349684,0.04502928,0.0001417426,0.00007758506,0.00003562701,0.0008087544,0.003984495,0.9391413,0.002549794,0.0003633233,0.0002370659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941862,0.0002347421,0.001217911,0.00006953039,0.0003564109,0.0003081175,0.00001829835,0.00003115655,0.003577658],"genre_scores_gemma":[0.9986272,0.00002378965,0.001079801,0.0000890115,0.00004012841,0.000007336081,0.00007523473,0.00001815589,0.00003930689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04365031,"threshold_uncertainty_score":0.4219495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0281617838342634,"score_gpt":0.2459548166266301,"score_spread":0.2177930327923667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}