{"id":"W1840818938","doi":"10.1080/15384101.2014.998056","title":"Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition","year":2015,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kootenay Association for Science & Technology","funders":"","keywords":"Transactivation; Isothermal titration calorimetry; Circular dichroism; Biology; Mdm2; Biophysics; Mutagenesis; Phosphorylation; Binding site; Computational biology; Plasma protein binding; Biochemistry; Transcription factor; Cell biology; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001013393,0.0001432047,0.000139692,0.0001058843,0.0002002915,0.0001790136,0.0001499606,0.000196239,0.0005033512],"category_scores_gemma":[0.0002180663,0.00008985387,0.000108307,0.00007338279,0.0002276755,0.0002247131,0.0001488592,0.000249416,0.0001395929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001381297,"about_ca_system_score_gemma":0.0001371813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002054754,"about_ca_topic_score_gemma":0.0002505293,"domain_scores_codex":[0.9999332,0.00001612996,0.000002911818,0.00001349047,0.00001686219,0.00001744577],"domain_scores_gemma":[0.9998825,0.00002706424,0.00002993471,0.000006368693,0.00001507296,0.00003917762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002747967,0.00003072118,0.001211646,0.00003090609,0.000006998681,0.0002764087,0.00005074931,0.000640396,0.9952908,0.0004766588,0.00004305564,0.0016669],"study_design_scores_gemma":[0.00009731061,0.0006312896,0.03383715,0.0000174573,0.00004104765,0.00142039,0.0003342418,0.02045549,0.9387805,0.0017226,0.002627137,0.0000351525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983949,0.0002407349,0.000850907,0.00002792689,0.0000046238,0.000003134721,0.00001581435,0.000006874052,0.0004550965],"genre_scores_gemma":[0.9994319,0.00006542692,0.0003692645,0.00001879736,0.000002441073,0.000002262689,0.00002787106,0.000001633118,0.00008042101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005033512,"threshold_uncertainty_score":0.001683891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0281617838342634,"score_gpt":0.2459548166266301,"score_spread":0.2177930327923667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}