{"id":"W1842227014","doi":"10.1038/cdd.2015.69","title":"NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis","year":2015,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Partenariat Canadien Contre Le Cancer; Université de Liège; Fundação para a Ciência e a Tecnologia; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Fonds De La Recherche Scientifique - FNRS; Vlaamse regering; Universiteit Gent; European Commission","keywords":"FADD; Cell biology; Apoptosis; Programmed cell death; Kinase; Phosphorylation; TRADD; Necroptosis; TRAF2; Biology; Caspase; Signal transduction; Death domain; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009306343,0.0001380361,0.0001223681,0.00002879121,0.00009019896,0.00002869222,0.00009681792,0.0001611056,0.000007622305],"category_scores_gemma":[0.00002879536,0.0001016586,0.00005376364,0.0000664898,0.00002597617,0.00001519903,0.00008462682,0.0000632475,0.000001813986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001820884,"about_ca_system_score_gemma":0.00004522178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000820012,"about_ca_topic_score_gemma":0.00001995706,"domain_scores_codex":[0.9991465,0.00007222073,0.0001935452,0.0002587961,0.0001936017,0.000135372],"domain_scores_gemma":[0.999407,0.00000574743,0.0001885899,0.0002143113,0.000124049,0.00006030938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000397767,0.00006828641,0.002934343,0.00002829411,0.00002113315,1.373269e-7,0.0003327014,0.00002830537,0.9904296,0.0006095927,0.00003471711,0.005473095],"study_design_scores_gemma":[0.0007040662,0.0002243686,0.009383684,0.00001409742,0.00003626335,0.000003891268,0.000119801,0.0003830904,0.9849533,0.003729401,0.0003248934,0.0001231444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894246,0.0002548456,0.008566384,0.00003204186,0.00048922,0.0003025684,0.000009996122,0.000008842084,0.0009114475],"genre_scores_gemma":[0.998642,0.00009553768,0.000429137,0.00002239781,0.0001491392,0.0000145487,0.0001236944,0.00001438217,0.0005091677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009217341,"threshold_uncertainty_score":0.4145519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0215349768261684,"score_gpt":0.2385667173936819,"score_spread":0.2170317405675135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}