{"id":"W1843766852","doi":"10.1038/mtna.2015.29","title":"Reducing IRF-1 to Levels Observed in HESN Subjects Limits HIV Replication, But Not the Extent of Host Immune Activation","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"","keywords":"Transactivation; Biology; Gene knockdown; Ex vivo; Immune system; Virology; Flow cytometry; Viral replication; Reverse transcriptase; Immunology; Gene; Gene expression; Polymerase chain reaction; In vivo; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003223597,0.0002972092,0.0003832258,0.0001868862,0.0002164522,0.0002127062,0.0001210622,0.0002877522,0.005122915],"category_scores_gemma":[0.0002472928,0.0001028462,0.0001839364,0.00008801626,0.0003904663,0.0001330024,0.0001791217,0.0003748774,0.0005555583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001465306,"about_ca_system_score_gemma":0.0001099884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001820089,"about_ca_topic_score_gemma":0.0002715489,"domain_scores_codex":[0.9999143,0.00001543593,0.000007438384,0.00003089411,0.00001645768,0.00001548315],"domain_scores_gemma":[0.9999197,0.00001404212,0.0000180997,0.00001386681,0.00001125469,0.00002311497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003669604,0.0008288896,0.01673356,0.0001368963,0.00005425356,0.001613928,0.0001898769,0.0001491938,0.9540331,0.0004891088,0.0005774217,0.02152424],"study_design_scores_gemma":[0.000937643,0.01654013,0.3312861,0.0001002575,0.0003177984,0.01638938,0.0009351568,0.003549985,0.6048861,0.001882003,0.02311496,0.00006042293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965669,0.0002119072,0.001159715,0.00009130839,0.00003837574,0.00003989056,0.000193405,0.00002586338,0.001672573],"genre_scores_gemma":[0.994789,0.0001610506,0.0007101477,0.0001492005,0.00002356718,0.0000872616,0.000286129,0.00001766181,0.003775947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005122915,"threshold_uncertainty_score":0.01713789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05886342397346205,"score_gpt":0.2888720871614673,"score_spread":0.2300086631880053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}