{"id":"W1845635296","doi":"10.1016/j.jacc.2015.05.049","title":"Clinical Trial Design Principles and Endpoint Definitions for Transcatheter Mitral Valve Repair and Replacement: Part 2: Endpoint Definitions","year":2015,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":574,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Hôpital du Sacré-Cœur de Montréal","funders":"","keywords":"Medicine; Mitral regurgitation; Clinical trial; Clinical endpoint; Mitral valve; Heart failure; Intensive care medicine; Cardiology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.4044161,0.005962281,0.01272307,0.006151867,0.002968132,0.009630009,0.006179352,0.01237327,0.004390867],"category_scores_gemma":[0.3932387,0.00397711,0.01391648,0.005507871,0.005587214,0.004453028,0.004560803,0.02323677,0.003169826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003581776,"about_ca_system_score_gemma":0.01058597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004596754,"about_ca_topic_score_gemma":0.0007627626,"domain_scores_codex":[0.42037,0.4760341,0.07173954,0.008877154,0.02034248,0.002636745],"domain_scores_gemma":[0.6125368,0.2843762,0.03476441,0.03325941,0.03132305,0.003740065],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.04779792,0.002351393,0.01638098,0.06688995,0.02289094,0.0007043759,0.004489966,0.01311657,0.006777795,0.3575965,0.139379,0.3216247],"study_design_scores_gemma":[0.07228854,0.01367303,0.02372893,0.04097152,0.02339852,0.00269582,0.0005643443,0.03806441,0.0106323,0.3469285,0.4257046,0.001349341],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.006430985,0.03650089,0.7434531,0.01665203,0.006909986,0.172301,0.006087011,0.001416558,0.0102484],"genre_scores_gemma":[0.02778889,0.004985298,0.5091302,0.01328627,0.002583127,0.4374773,0.002675075,0.000395802,0.001678022],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.5955839,"threshold_uncertainty_score":0.7344611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1732421368236726,"score_gpt":0.3829350946271391,"score_spread":0.2096929578034665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}