{"id":"W1846100490","doi":"10.1016/j.cell.2015.08.037","title":"Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells","year":2015,"lang":"en","type":"article","venue":"Cell","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":223,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Center for Individualized Medicine, Mayo Clinic; National Institutes of Health; Mayo Clinic","keywords":"Biology; Provirus; SUMO protein; Chromatin; Gene silencing; Embryonic stem cell; Genetics; Psychological repression; Histone; Endogenous retrovirus; Retrotransposon; Epigenetics; Polycomb-group proteins; Cell biology; Genome; Transcription factor; Repressor; Gene; Gene expression; Transposable element","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000598884,0.0006389749,0.0004947817,0.0009676269,0.000383698,0.0007605546,0.0004863611,0.0003093551,0.001598402],"category_scores_gemma":[0.0005170511,0.000469925,0.0007180719,0.0004544398,0.0005285504,0.0003870161,0.0004514356,0.00103515,0.0009066327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008215166,"about_ca_system_score_gemma":0.0009731806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001065807,"about_ca_topic_score_gemma":0.002261329,"domain_scores_codex":[0.9996322,0.0000477844,0.00005809882,0.0000829151,0.0001142954,0.00006459818],"domain_scores_gemma":[0.9994276,0.0002275403,0.0001064848,0.0001060288,0.00006575441,0.00006645639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003328926,0.00001031688,0.000127283,0.00001905382,0.000004086485,0.00002498356,0.000009832087,0.00003428464,0.9980795,0.0002283319,0.00002111179,0.001407851],"study_design_scores_gemma":[0.000006227721,0.00004801813,0.0007083685,0.000003466004,0.00002173554,0.00008669757,0.00001552541,0.0002391346,0.9968596,0.00007472236,0.001933577,0.00000303934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8956445,0.006190138,0.08899534,0.0003249938,0.00009619047,0.0004791465,0.002217108,0.0006750019,0.005377565],"genre_scores_gemma":[0.9481602,0.002420474,0.04019195,0.0001408889,0.0000274297,0.0001743567,0.0034555,0.0004345935,0.004994513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001598402,"threshold_uncertainty_score":0.005960524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03373046061763461,"score_gpt":0.2919876332322461,"score_spread":0.2582571726146115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}