{"id":"W1846100490","doi":"10.1016/j.cell.2015.08.037","title":"Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells","year":2015,"lang":"en","type":"article","venue":"Cell","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":223,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Center for Individualized Medicine, Mayo Clinic; National Institutes of Health; Mayo Clinic","keywords":"Biology; Provirus; SUMO protein; Chromatin; Gene silencing; Embryonic stem cell; Genetics; Psychological repression; Histone; Endogenous retrovirus; Retrotransposon; Epigenetics; Polycomb-group proteins; Cell biology; Genome; Transcription factor; Repressor; Gene; Gene expression; Transposable element","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006289243,0.00008463623,0.0001553607,0.00006176824,0.00001595633,0.00001203174,0.0001850116,0.00007928926,0.000001626856],"category_scores_gemma":[0.00003951684,0.00007626635,0.00005621824,0.00008198432,0.0000236687,0.000003095646,0.00003178989,0.00003949911,0.00001041009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003724408,"about_ca_system_score_gemma":0.0001411425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001045554,"about_ca_topic_score_gemma":0.00004004963,"domain_scores_codex":[0.9991271,0.00009718959,0.0002825115,0.0001949616,0.0001332184,0.0001650571],"domain_scores_gemma":[0.9993509,0.00003018206,0.0001361114,0.0003145269,0.0001130921,0.0000551741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001973766,0.00004454127,0.0001000076,0.002084461,0.00001080927,2.523214e-7,0.0002269748,0.0002905436,0.9968829,0.000001612671,0.0001189531,0.0000416157],"study_design_scores_gemma":[0.0005839805,0.0006741469,0.00002016394,0.00007834563,0.000008786409,2.490453e-7,0.0007866566,0.0003620587,0.9973662,0.00001437888,0.00002729726,0.00007767531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973558,0.001141814,0.0005011297,0.000006751719,0.00009527865,0.0008075539,0.00001463175,0.000004620342,0.00007238347],"genre_scores_gemma":[0.9984819,0.0000234474,0.00003044676,0.000008185278,0.00002826967,0.00007530598,0.00002086196,0.0000177032,0.001313911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002006116,"threshold_uncertainty_score":0.3110051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03373046061763461,"score_gpt":0.2919876332322461,"score_spread":0.2582571726146115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}