{"id":"W1847056372","doi":"10.1111/ajt.12447","title":"RIPK3-Mediated Necroptosis Promotes Donor Kidney Inflammatory Injury and Reduces Allograft Survival","year":2013,"lang":"en","type":"article","venue":"American Journal of Transplantation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":206,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Genentech; Kidney Foundation of Canada; London Health Sciences Centre","keywords":"Necroptosis; RIPK1; Medicine; Necrosis; Transplantation; Programmed cell death; Tumor necrosis factor alpha; Cancer research; Kidney; Alloimmunity; Apoptosis; Immunology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004568632,0.0004712869,0.0005159466,0.0003359697,0.0003053242,0.0006645233,0.0003385325,0.0004026879,0.003110278],"category_scores_gemma":[0.0003002408,0.000203935,0.0005523007,0.0002490703,0.0004321808,0.0003533151,0.0003632376,0.001757582,0.0006478359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005503514,"about_ca_system_score_gemma":0.0005899182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003436877,"about_ca_topic_score_gemma":0.00071286,"domain_scores_codex":[0.9996161,0.00006010175,0.00004211469,0.00005205561,0.0001068839,0.0001227273],"domain_scores_gemma":[0.9997367,0.00002037408,0.00009766549,0.00004302676,0.00001879082,0.00008342102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002112454,0.0003300523,0.001196581,0.0001051524,0.00003967029,0.0001118899,0.00001656118,0.0002316561,0.990668,0.0002458412,0.0003668074,0.004575447],"study_design_scores_gemma":[0.0002824378,0.001449692,0.02464087,0.00002307637,0.0001358447,0.001528876,0.00009447218,0.002565789,0.9656232,0.0004759055,0.003154448,0.00002529254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937707,0.001415096,0.002152843,0.0002902051,0.0001056329,0.00003978042,0.0003350299,0.0002428417,0.00164786],"genre_scores_gemma":[0.9966239,0.0004403416,0.00100542,0.0001214675,0.00002317636,0.00003514509,0.0003500673,0.00003739578,0.001363168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003110278,"threshold_uncertainty_score":0.01040494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003319793783608004,"score_gpt":0.2081955307741996,"score_spread":0.2048757369905916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}