{"id":"W184764596","doi":"10.1161/circ.118.suppl_18.s_754-b","title":"Abstract 2618: Bone Morphogenic Protein-9 Stimulates Endothelin-1 Synthesis by Human Pulmonary Microvascular Endothelial Cells: A Possible Contributor to the Pathogenesis of Pulmonary Arterial Hypertension","year":2008,"lang":"en","type":"article","venue":"Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Endothelin 1; BMPR2; Endocrinology; Pathogenesis; Internal medicine; Pulmonary hypertension; Endothelin receptor; Lung; Endothelial stem cell; Bone morphogenetic protein receptor; Bone morphogenetic protein; Receptor; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001587636,0.0004541776,0.0002607464,0.0001952939,0.0001245865,0.0002496294,0.0001830434,0.00033984,0.006832249],"category_scores_gemma":[0.0001714433,0.000144292,0.000287016,0.0001373309,0.0001630467,0.0001883084,0.000197429,0.000571909,0.001480538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001678839,"about_ca_system_score_gemma":0.0001293842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003907227,"about_ca_topic_score_gemma":0.0003514835,"domain_scores_codex":[0.9998614,0.00003693807,0.00001110721,0.00001432343,0.00004059493,0.00003561499],"domain_scores_gemma":[0.9999093,0.00003101212,0.00001083928,0.000006319722,0.00001182552,0.00003078799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008553138,0.0001919462,0.0005279458,0.0001216856,0.000009784529,0.000360378,0.00002017963,0.00004394223,0.9939454,0.00008133694,0.0004282619,0.003413793],"study_design_scores_gemma":[0.0004344491,0.003948144,0.02654613,0.00005389758,0.00005159794,0.002086649,0.00007914464,0.0009756548,0.950711,0.0001781495,0.01492667,0.000008625077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861897,0.004879578,0.001519671,0.0006466312,0.0002786934,0.00008723616,0.001148075,0.00006663035,0.005183764],"genre_scores_gemma":[0.9754518,0.004224658,0.004584096,0.0004307401,0.0002887322,0.0001664847,0.002698454,0.00002691163,0.01212821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006832249,"threshold_uncertainty_score":0.02285612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02415919898266325,"score_gpt":0.2456082832061696,"score_spread":0.2214490842235063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}