{"id":"W1848034928","doi":"10.1182/blood-2014-11-612903","title":"Eradication of B-ALL using chimeric antigen receptor–expressing T cells targeting the TSLPR oncoprotein","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"National Center for Research Resources; National Cancer Institute","keywords":"Chimeric antigen receptor; Antigen; Receptor; Adoptive cell transfer; Genetically engineered; Molecular biology; Cell biology; Chemistry; Biology; Virology; Immunology; T cell; Immune system; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001676046,0.000417272,0.0002781322,0.0002219801,0.0001060783,0.0002982324,0.0001853956,0.0002718572,0.0006331626],"category_scores_gemma":[0.0001051652,0.0001071674,0.0002292766,0.0001837268,0.0002224972,0.000218157,0.000184528,0.0007283565,0.0002561419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002455242,"about_ca_system_score_gemma":0.0002426343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005980911,"about_ca_topic_score_gemma":0.0006205628,"domain_scores_codex":[0.999885,0.00002008029,0.000009036053,0.00001972826,0.00002662392,0.00003951621],"domain_scores_gemma":[0.9999316,0.00001539831,0.00001857518,0.000009651834,0.00000568545,0.00001908908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002589932,0.000157778,0.0002476675,0.0000462229,0.00001368173,0.00006001321,0.00002749477,0.0002659204,0.9920169,0.0001900897,0.0001341992,0.006580962],"study_design_scores_gemma":[0.0001482338,0.003582933,0.001828,0.000005180444,0.0000468301,0.0005611833,0.00001817393,0.001934947,0.9875736,0.00006427255,0.004230481,0.000006196326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937552,0.001190022,0.003598006,0.00007665739,0.00001818662,0.00005694857,0.0001134779,0.0001832497,0.001008115],"genre_scores_gemma":[0.9960049,0.0006249518,0.001955855,0.00003650159,0.00001493954,0.00004893974,0.0002608354,0.00002352831,0.001029512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006331626,"threshold_uncertainty_score":0.002118111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0622499523900424,"score_gpt":0.3304704845190863,"score_spread":0.2682205321290439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}