{"id":"W1848034928","doi":"10.1182/blood-2014-11-612903","title":"Eradication of B-ALL using chimeric antigen receptor–expressing T cells targeting the TSLPR oncoprotein","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"National Center for Research Resources; National Cancer Institute","keywords":"Chimeric antigen receptor; Antigen; Receptor; Adoptive cell transfer; Genetically engineered; Molecular biology; Cell biology; Chemistry; Biology; Virology; Immunology; T cell; Immune system; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008468543,0.000117087,0.0002310977,0.0000878405,0.00007542905,0.00002491137,0.0001704852,0.00007583573,0.0003928483],"category_scores_gemma":[0.0001503742,0.00008561854,0.00007810938,0.0003054134,0.0001167517,0.00007018419,0.00006502399,0.0002419708,0.00003082423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005985359,"about_ca_system_score_gemma":0.0002420409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002834967,"about_ca_topic_score_gemma":0.000002003809,"domain_scores_codex":[0.9985569,0.0001494769,0.000285836,0.0002099604,0.0005229029,0.0002749184],"domain_scores_gemma":[0.9990642,0.0000642934,0.0001652263,0.0003972651,0.0001695483,0.0001394442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008264243,0.0002248888,0.002422336,0.00003730464,0.00008525787,0.000004479361,0.001225806,0.00003048749,0.9908268,0.000005150523,0.0004838383,0.004570951],"study_design_scores_gemma":[0.001900629,0.0001695003,0.0003811417,0.0001156666,0.00007767933,0.00001983846,0.0003122764,0.0008712843,0.9828095,0.00003858393,0.01320617,0.00009773842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935299,0.001781048,0.0002697493,0.0003359843,0.000120711,0.0005580291,0.000003123399,0.00003810403,0.003363415],"genre_scores_gemma":[0.9861238,0.000108004,0.0123737,0.0001046555,0.0004895749,0.0000120732,0.00001813218,0.00004373521,0.0007263309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01272233,"threshold_uncertainty_score":0.4301413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0622499523900424,"score_gpt":0.3304704845190863,"score_spread":0.2682205321290439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}