{"id":"W1848220679","doi":"10.1186/1471-2407-3-21","title":"Therapeutic limitations in tumor-specific CD8+ memory T cell engraftment","year":2003,"lang":"en","type":"article","venue":"BMC Cancer","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; U.S. Department of Defense","keywords":"CTL*; Adoptive cell transfer; Cytotoxic T cell; CD8; Immunotherapy; Immunology; Cancer research; Ex vivo; Medicine; T cell; Cell therapy; In vivo; Biology; Immune system; In vitro; Stem cell; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002821425,0.0001384151,0.0002145865,0.0001763707,0.00004770401,0.00002062202,0.00008182699,0.00004990823,0.008703247],"category_scores_gemma":[0.00002525959,0.0001243099,0.00009518449,0.0003928797,0.00006345965,0.00004065703,0.00001332231,0.0002550919,0.0001717066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00049066,"about_ca_system_score_gemma":0.0004386897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001125148,"about_ca_topic_score_gemma":0.0007333162,"domain_scores_codex":[0.9986576,0.0001225321,0.0002177979,0.0002851999,0.0003581674,0.0003586723],"domain_scores_gemma":[0.9992297,0.0001696904,0.00003729767,0.0003646925,0.00007552001,0.0001231445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001276581,0.001976607,0.07854608,0.0004540244,0.0001647302,0.0002150438,0.005438818,0.0009618046,0.7678012,0.002927052,0.01455864,0.1256794],"study_design_scores_gemma":[0.005734873,0.0002727956,0.05580296,0.00009961266,0.00003833604,0.00002723662,0.001520585,0.0001592281,0.1332283,0.0004868264,0.8023138,0.0003154636],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7313542,0.02310203,0.0001899886,0.0007549886,0.0005610449,0.001610468,0.00001068505,0.00008260861,0.242334],"genre_scores_gemma":[0.9393044,0.001976704,0.0005298129,0.0006489162,0.0001586979,0.0003792134,0.000005963882,0.00004579352,0.05695057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7877551,"threshold_uncertainty_score":0.9922029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1312898304289417,"score_gpt":0.3417320469958789,"score_spread":0.2104422165669372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}