{"id":"W1848757588","doi":"10.1038/ncomms8060","title":"A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Montreal General Hospital; Jewish General Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Mendelian randomization; Confounding; Type 2 diabetes; Medicine; Observational study; Odds ratio; Internal medicine; Diabetes mellitus; Randomization; Case-control study; Randomized controlled trial; Cardiology; Endocrinology; Genetics; Biology; Genetic variants; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004458168,0.00006431926,0.0001417753,0.0000228719,0.0000653375,0.000001878805,0.0003771465,0.000106711,0.000001288763],"category_scores_gemma":[0.001294599,0.00004303779,0.00005191914,0.0001295546,0.00006541536,0.000001220837,0.000186468,0.0001350937,0.000001122923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000973088,"about_ca_system_score_gemma":0.00004887952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008274545,"about_ca_topic_score_gemma":0.00004725789,"domain_scores_codex":[0.9988681,0.0007170514,0.0001677796,0.00009438895,0.00008516342,0.00006751189],"domain_scores_gemma":[0.9985111,0.0001490987,0.0001199863,0.001033259,0.0001481371,0.00003836813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000274916,0.0002554775,0.9858421,0.000005289259,0.00007077415,2.070677e-8,0.00007762472,0.001013633,0.004875402,0.00007806055,0.007320395,0.0001862719],"study_design_scores_gemma":[0.004231782,0.002084655,0.981793,0.00001998558,0.0001552324,4.109741e-7,0.0001887581,0.000712303,0.003835444,0.0001373806,0.006725255,0.0001157562],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996038,0.002038461,0.000005838136,0.001097579,0.0001065644,0.0004061481,0.00001522838,0.000003375624,0.0002888463],"genre_scores_gemma":[0.9994283,0.00004623956,0.0001517101,0.0001747482,0.00001771553,0.00003534732,0.00008868688,0.000006524534,0.0000507677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004049098,"threshold_uncertainty_score":0.175503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01549777713383392,"score_gpt":0.3071615116527478,"score_spread":0.2916637345189139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}