{"id":"W1848835470","doi":"10.1016/j.bbamem.2015.10.018","title":"Molecular mechanisms of membrane targeting antibiotics","year":2015,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":656,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Bacteria; Antimicrobial; Periplasmic space; Bacterial outer membrane; Gram-negative bacteria; Antimicrobial peptides; Bacterial cell structure; Biochemistry; Lipid A; Chemistry; Membrane; Lipid II; Microbiology; Biology; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002858399,0.0006776071,0.0009018616,0.0008890527,0.0002107038,0.0009830362,0.0006789377,0.0009629086,0.001357819],"category_scores_gemma":[0.0002548557,0.0002631397,0.0002664753,0.0007386601,0.0005821463,0.001382666,0.0007484732,0.00126311,0.0009993807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005993582,"about_ca_system_score_gemma":0.0006285884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002725238,"about_ca_topic_score_gemma":0.0003536991,"domain_scores_codex":[0.9998807,0.00001792352,0.00001396591,0.00002004301,0.00004048321,0.00002692433],"domain_scores_gemma":[0.9999294,0.00002308973,0.0000190123,0.000003651792,0.00001557236,0.000009255946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002077524,0.0001133409,0.000214247,0.01507718,0.00006944207,0.0006581438,0.0001277484,0.0008798089,0.0527794,0.01760907,0.01418876,0.8980751],"study_design_scores_gemma":[0.00002567875,0.000135006,0.0007150566,0.00147892,0.00007867805,0.001866518,0.00006983006,0.0003220117,0.01587375,0.00544229,0.9739658,0.00002646653],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006912872,0.997166,0.0004624585,0.0002940001,0.0001548165,0.000006151799,0.00001834624,0.000009691273,0.001197151],"genre_scores_gemma":[0.004564399,0.9935492,0.000351624,0.0001800073,0.0001434038,0.00001196726,0.00002976077,0.00000152846,0.001168137],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001357819,"threshold_uncertainty_score":0.004542351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02700378502524797,"score_gpt":0.2869824998136219,"score_spread":0.2599787147883739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}