{"id":"W1849869421","doi":"10.1111/j.1365-2958.2012.08134.x","title":"Regulated expression of cyclic AMP‐dependent protein kinase A reveals an influence on cell size and the secretion of virulence factors in <i>Cryptococcus neoformans</i>","year":2012,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Burroughs Wellcome Fund","keywords":"Biology; Cryptococcus neoformans; Secretion; Virulence; Protein kinase A; Extracellular; Intracellular; Virulence factor; Protein subunit; Biochemistry; Cell biology; Kinase; Gene; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009909327,0.0002504426,0.0001329632,0.0001890659,0.00009625934,0.000248241,0.0001293778,0.0001648643,0.0005235251],"category_scores_gemma":[0.0001385152,0.0001081774,0.000138427,0.0001095436,0.000224278,0.0001179349,0.0001498583,0.0003759224,0.0001752927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000454004,"about_ca_system_score_gemma":0.000168024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000976905,"about_ca_topic_score_gemma":0.001105734,"domain_scores_codex":[0.9998927,0.00001873341,0.000009580635,0.0000220823,0.000025849,0.00003109836],"domain_scores_gemma":[0.9998522,0.00004040785,0.00004077245,0.00001546227,0.00001095549,0.00004024654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003756418,0.000008623964,0.00007797417,0.00000360618,5.231858e-7,0.00001217995,0.000002921321,0.00001251918,0.999617,0.000014708,0.000004088903,0.0002083656],"study_design_scores_gemma":[0.000004777983,0.0001292594,0.004954257,0.000001695473,0.000003885795,0.0001051449,0.00001292659,0.0004282666,0.9940606,0.00001834602,0.0002783199,0.000002590903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985477,0.0001765543,0.0005398241,0.00004249136,0.000006260713,0.000007219064,0.0001483247,0.00002206886,0.0005095089],"genre_scores_gemma":[0.9979423,0.0001294903,0.0009929287,0.00002417435,0.000003664904,0.000009395683,0.0002264267,0.00001191185,0.0006596004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000976905,"threshold_uncertainty_score":0.003294051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007474468722634338,"score_gpt":0.2406567885272621,"score_spread":0.2331823198046278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}