{"id":"W1851069093","doi":"10.1016/j.parkreldis.2015.07.025","title":"Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release","year":2015,"lang":"en","type":"article","venue":"Parkinsonism & Related Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Toronto Centre for Phenogenomics","funders":"Michael J. Fox Foundation for Parkinson's Research","keywords":"Dopamine; LRRK2; Dopaminergic; Neuroscience; Gene silencing; Parkinson's disease; Dopamine transporter; Biology; Psychology; Endocrinology; Internal medicine; Medicine; Genetics; Disease; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001578157,0.0004199939,0.0005593096,0.0001890911,0.0002023882,0.00006268691,0.00004583731,0.0002883167,0.00001671868],"category_scores_gemma":[0.0001393015,0.0003724412,0.00005039326,0.0002041055,0.0002997941,0.0002834689,0.0001204193,0.0002606604,0.0000051763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009883569,"about_ca_system_score_gemma":0.0001825075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003535523,"about_ca_topic_score_gemma":0.0000336163,"domain_scores_codex":[0.9980707,0.0001377481,0.0003855812,0.0006884164,0.0003455505,0.0003719901],"domain_scores_gemma":[0.9986564,0.000115736,0.0002764799,0.0002333882,0.0001820735,0.0005359464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.006670213,0.001504111,0.1696037,0.001277296,0.001510148,0.0003412891,0.003170531,0.00000910215,0.2987761,0.00005388438,0.00006339819,0.5170203],"study_design_scores_gemma":[0.0513226,0.01127721,0.8823714,0.006335362,0.006762173,0.0006583213,0.0006762802,0.005807112,0.03101235,0.0008708419,0.001527301,0.001379016],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776175,0.0205477,0.00007457293,0.00006754192,0.0001367259,0.001328809,0.00004877635,0.00006818127,0.0001102214],"genre_scores_gemma":[0.9955438,0.003803526,0.0001786561,0.00003029092,0.00004078085,0.00006029283,0.0001470136,0.00006198188,0.0001336042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7127678,"threshold_uncertainty_score":0.9998727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629350187786088,"score_gpt":0.2668970136938085,"score_spread":0.2506035118159476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}