{"id":"W1851359940","doi":"10.1002/9780470015902.a0024402","title":"<scp>GLI</scp> Proteins in Human Genetic Disease","year":2012,"lang":"en","type":"other","venue":"Encyclopedia of Life Sciences","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Cilium; Ciliogenesis; GLI2; Biology; GLI3; Phenotype; Genetics; Ciliopathies; Hedgehog signaling pathway; Transcription factor; Hedgehog; Repressor; Loss function; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003387713,0.0002901391,0.0003345358,0.0002407087,0.00008444714,0.00001152556,0.0005946348,0.0002080036,0.00007887655],"category_scores_gemma":[0.0006549632,0.0002548598,0.0001008525,0.0002520745,0.0006678198,0.000003753168,0.0002320963,0.0001135621,0.00002470978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008383079,"about_ca_system_score_gemma":0.000355616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001385252,"about_ca_topic_score_gemma":0.0001833283,"domain_scores_codex":[0.9981704,0.0001012223,0.0003444418,0.000556029,0.0003664394,0.0004614446],"domain_scores_gemma":[0.9990619,0.00002830125,0.000279404,0.0003773488,0.00003057227,0.0002224336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000104817,0.0006313671,0.3372896,0.0007683859,0.0001759615,0.00002682043,0.0007291213,0.0001068679,0.0346109,0.0003808392,0.623474,0.001795648],"study_design_scores_gemma":[0.0002625025,0.0001887159,0.02303291,0.000181846,0.00003172852,6.87474e-7,0.0001354597,0.000002532368,0.001912812,0.0001158512,0.9739192,0.0002157701],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.2190603,0.04358871,0.0001134966,0.00005523852,0.000686268,0.0008219441,0.0001106034,0.00004617694,0.7355173],"genre_scores_gemma":[0.2966655,0.008778421,0.008104249,0.0003348474,0.0052219,0.0003769582,0.0001037254,0.0005044558,0.6799099],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.3504452,"threshold_uncertainty_score":0.9999903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01681989977733967,"score_gpt":0.267605256748606,"score_spread":0.2507853569712663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}