{"id":"W1851435020","doi":"10.4049/jimmunol.180.4.2284","title":"ICOS, CD40, and Lymphotoxin β Receptors Signal Sequentially and Interdependently to Initiate a Germinal Center Reaction","year":2008,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Lymphotoxin; Germinal center; Lymphotoxin beta receptor; Receptor; Center (category theory); CD40; SIGNAL (programming language); Syrinx (medicine); Biology; Cell biology; Immunology; Computer science; Neuroscience; B cell; Chemistry; Antibody; Programming language; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007345538,0.0002161359,0.0004058459,0.0002988322,0.0003515142,0.00001562891,0.0003069823,0.0002217406,0.0002746435],"category_scores_gemma":[0.00008519442,0.0001498532,0.00009390434,0.0001149233,0.0006033877,0.000219836,0.000154944,0.0005522571,0.00008011712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006810178,"about_ca_system_score_gemma":0.000124529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001137298,"about_ca_topic_score_gemma":0.00001144653,"domain_scores_codex":[0.9979684,0.0008882008,0.0005906522,0.0001482925,0.00005738232,0.0003471175],"domain_scores_gemma":[0.9989303,0.0002993154,0.00039423,0.0002023761,0.0001448942,0.00002882244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007435751,0.0001098092,0.0004169047,0.00000502912,0.000554895,0.00004308858,0.003597839,7.695339e-7,0.9710113,0.00003753738,0.0007930507,0.01599396],"study_design_scores_gemma":[0.009877398,0.006320688,0.04665494,0.000271674,0.0002378103,0.1289219,0.00272815,0.000001759988,0.6747652,0.000404953,0.1292278,0.0005877955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798414,0.01778171,0.0003462773,0.0006070468,0.001112312,0.0001578066,0.000006353174,0.00001577204,0.0001313941],"genre_scores_gemma":[0.9886229,0.009694998,0.0000627707,0.0005240559,0.00004672125,0.000003779076,0.000004869265,0.0000211825,0.001018699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2962462,"threshold_uncertainty_score":0.6110837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01511479680437022,"score_gpt":0.2391800886994451,"score_spread":0.2240652918950749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}