{"id":"W1851435020","doi":"10.4049/jimmunol.180.4.2284","title":"ICOS, CD40, and Lymphotoxin β Receptors Signal Sequentially and Interdependently to Initiate a Germinal Center Reaction","year":2008,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Lymphotoxin; Germinal center; Lymphotoxin beta receptor; Receptor; Center (category theory); CD40; SIGNAL (programming language); Syrinx (medicine); Biology; Cell biology; Immunology; Computer science; Neuroscience; B cell; Chemistry; Antibody; Programming language; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001939864,0.0009716825,0.0004685107,0.0005007323,0.0001774508,0.000556534,0.0002890556,0.000404356,0.001249527],"category_scores_gemma":[0.0001472042,0.0003184959,0.0004214413,0.0002296262,0.000391944,0.0003966689,0.0003230534,0.001161463,0.0005542117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004335061,"about_ca_system_score_gemma":0.0002506614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004689336,"about_ca_topic_score_gemma":0.0005582551,"domain_scores_codex":[0.9996685,0.0000350432,0.00003358896,0.00008759033,0.00006327018,0.0001120607],"domain_scores_gemma":[0.9994417,0.0000375277,0.0002208665,0.00005775091,0.00004388211,0.0001982487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001360209,0.00001730856,0.0002314325,0.00002516292,0.000003700035,0.00004865318,0.000009909362,0.00002105487,0.9987852,0.00008076907,0.0000236224,0.0006172276],"study_design_scores_gemma":[0.00003247228,0.0003630551,0.007270318,0.00001126976,0.00003412344,0.0004953748,0.00005988896,0.0004503673,0.9890326,0.00007307308,0.002173542,0.000003948207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913716,0.002391885,0.003170272,0.0000863867,0.00006549004,0.00006080058,0.0002979331,0.0002627583,0.00229282],"genre_scores_gemma":[0.9906974,0.001024275,0.003876174,0.000113716,0.000055194,0.00006532702,0.0005632903,0.00006529874,0.003539297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001249527,"threshold_uncertainty_score":0.004180074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01511479680437022,"score_gpt":0.2391800886994451,"score_spread":0.2240652918950749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}