{"id":"W1851676096","doi":"10.1016/j.cellsig.2015.09.016","title":"Nck1 deficiency improves pancreatic β cell survival to diabetes-relevant stresses by modulating PERK activation and signaling","year":2015,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"mTORC1; Gene silencing; Autophagy; Cell biology; AMPK; Unfolded protein response; Protein kinase B; Downregulation and upregulation; Endoplasmic reticulum; Signal transduction; Viability assay; Cancer research; Biology; Chemistry; Cell; Apoptosis; Kinase; Protein kinase A; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005794019,0.0002814119,0.0004607855,0.0001511686,0.000165843,0.0000986749,0.00008644744,0.0001119079,0.00005312687],"category_scores_gemma":[0.0005892717,0.0002533093,0.00007352849,0.0003037781,0.00004810404,0.0001655688,0.00005486001,0.000198957,0.0000268799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009063858,"about_ca_system_score_gemma":0.0001076202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000553414,"about_ca_topic_score_gemma":4.024559e-7,"domain_scores_codex":[0.9980703,0.00008748636,0.0004128766,0.0004835006,0.0004718391,0.0004740172],"domain_scores_gemma":[0.9985836,0.0003622762,0.0001422365,0.0002275188,0.000200607,0.000483834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004844102,0.000100978,0.01571961,0.0002155226,0.00002949291,0.000004173279,0.0004902558,0.000990152,0.9808553,0.00002557979,0.0001544841,0.00136596],"study_design_scores_gemma":[0.001285516,0.0005693163,0.0005215237,0.000352837,0.0001867449,0.000001220008,0.00158158,0.02928731,0.9654125,0.0001705563,0.0002844277,0.0003464786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770927,0.002100121,0.01848729,0.0001270112,0.0001670301,0.0004225905,0.000008901799,0.000118069,0.001476321],"genre_scores_gemma":[0.9952306,0.00001687492,0.0036384,0.0002576483,0.0002026399,0.00002772057,0.00008665747,0.00005000068,0.0004895083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02829716,"threshold_uncertainty_score":0.9999919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02190890868230181,"score_gpt":0.2320901411366101,"score_spread":0.2101812324543083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}