{"id":"W1856053518","doi":"10.1038/emboj.2011.79","title":"STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation","year":2011,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":234,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Austrian Science Fund; Österreichischen Akademie der Wissenschaften; Heart and Stroke Foundation of Canada","keywords":"Biology; Transition (genetics); Intramolecular force; ORAI1; Biophysics; STIM1; Evolutionary biology; Computational biology; Cell biology; Genetics; Stereochemistry; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004846848,0.0001074555,0.00009787983,0.00008342545,0.0004557344,0.00008487057,0.000316,0.00004202989,0.0004198824],"category_scores_gemma":[0.00003781929,0.00006758844,0.00004844241,0.0001476002,0.00007601087,0.0006189833,0.0000158502,0.0002374128,0.00007518636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002765645,"about_ca_system_score_gemma":0.00003290729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002974276,"about_ca_topic_score_gemma":0.000009734785,"domain_scores_codex":[0.9989546,0.0001986048,0.0002316015,0.0001293345,0.0002789754,0.0002069018],"domain_scores_gemma":[0.9994755,0.00001603398,0.00009680094,0.000131855,0.00007117636,0.0002085815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000217001,0.000195911,0.00000202244,0.000007392995,0.00000731791,0.00003087514,0.05187308,0.001148146,0.9045667,0.001393782,0.0002981697,0.0402596],"study_design_scores_gemma":[0.0004871699,0.001011096,0.0002895594,0.00002846365,0.00002412498,0.0008439857,0.002739974,0.02605243,0.9539358,0.0135729,0.0007650122,0.0002494712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9305001,0.00001355156,0.06767508,0.0005211156,0.0006570004,0.0001500803,0.00000226267,0.0000381059,0.000442673],"genre_scores_gemma":[0.9976433,0.0000393903,0.0006689903,0.0013373,0.0002702501,0.000003903165,0.0000023836,0.0000135794,0.00002092177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06714315,"threshold_uncertainty_score":0.4597418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04815363481230631,"score_gpt":0.2799357706087167,"score_spread":0.2317821357964104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}