{"id":"W1856053518","doi":"10.1038/emboj.2011.79","title":"STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation","year":2011,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":234,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Austrian Science Fund; Österreichischen Akademie der Wissenschaften; Heart and Stroke Foundation of Canada","keywords":"Biology; Transition (genetics); Intramolecular force; ORAI1; Biophysics; STIM1; Evolutionary biology; Computational biology; Cell biology; Genetics; Stereochemistry; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002163053,0.0002742337,0.0001603674,0.00009691244,0.0002944809,0.0003099712,0.0003031497,0.0003082111,0.005528892],"category_scores_gemma":[0.0004088785,0.0001509472,0.0002884466,0.0001025118,0.0003255494,0.0007060304,0.0004513304,0.00094762,0.001116305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002401251,"about_ca_system_score_gemma":0.0001015594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000989006,"about_ca_topic_score_gemma":0.0001535623,"domain_scores_codex":[0.9999065,0.00001122694,0.000005165036,0.00003071921,0.00001826057,0.00002818472],"domain_scores_gemma":[0.9998088,0.00004729757,0.00005045557,0.00003442078,0.00001830252,0.00004067798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000301926,0.00005433644,0.0003297597,0.00009453182,0.00002781282,0.0002369209,0.0001430456,0.0001985246,0.992004,0.0022534,0.000381877,0.003973928],"study_design_scores_gemma":[0.00007119949,0.0002680481,0.005681935,0.00002630212,0.00002621967,0.000683609,0.0001399378,0.001866639,0.9798368,0.0008730731,0.01049613,0.00003018528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830924,0.001052822,0.006154915,0.0003734133,0.0001570801,0.00003082725,0.0001452209,0.0001352609,0.008858198],"genre_scores_gemma":[0.9928555,0.0003741769,0.001453448,0.0002476186,0.000050183,0.00003180567,0.0002731174,0.00003499691,0.004679121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005528892,"threshold_uncertainty_score":0.01849598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04815363481230631,"score_gpt":0.2799357706087167,"score_spread":0.2317821357964104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}